Neurons generated from carcinoma stem cells support cancer progression.
Neurons generated from carcinoma stem cells support cancer progression.
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癌症干细胞产生的神经元支持癌症进展
DOI：
10.1038/sigtrans.2016.36
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发表时间：
2017
影响因子：
39.3
通讯作者：
Mo X
中科院分区：
文献类型：
--
作者：
Lu R;Fan C;Shangguan W;Liu Y;Li Y;Shang Y;Yin D;Zhang S;Huang Q;Li X;Meng W;Xu H;Zhou Z;Hu J;Li W;Liu L;Mo X
近年来的研究表明，神经系统是肿瘤微环境的重要组成部分。神经纤维浸润到癌症微环境中在癌症进展中具有重要的积极作用。神经系统成员如神经元和神经胶质细胞对肿瘤生长和转移的刺激作用已得到证实。然而，神经系统如何在癌症中建立在很大程度上是未知的。在这里，我们表明，一部分来自胃癌和结直肠癌患者的癌症干细胞（CSCs）能够产生参与肿瘤神经发生和肿瘤生长的神经元。来源于单个癌症干细胞的癌症干细胞单克隆能够产生神经元，包括交感神经元和副交感神经元，以参与癌症组织中的神经系统。敲低人CSC的神经细胞生成能力抑制了小鼠模型中异种移植肿瘤的生长。我们的数据表明，人类CSC能够在癌症微环境中产生癌症发展和进展所需的最重要的成分之一。
Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression. The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated. However, how the nervous system is built in cancer is largely unknown. Here we show that a fraction of cancer stem cells (CSCs) derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth. Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues. Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model. Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression.
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影响因子：
11.5
作者：
Liebl, Florian;Demir, Ihsan Ekin;Ceyhan, Guealp O.
通讯作者：
Ceyhan, Guealp O.
影响因子：
50.3
作者：
Hanahan, Douglas;Coussens, Lisa M.
通讯作者：
Coussens, Lisa M.
影响因子：
45.3
作者：
Barron, Thomas I.;Connolly, Roisin M.;Visvanathan, Kala
通讯作者：
Visvanathan, Kala
影响因子：
64.8
作者：
Ricci-Vitiani, Lucia;Pallini, Roberto;De Maria, Ruggero
通讯作者：
De Maria, Ruggero
人类 MAP2 基因在黑色素瘤中的转录调控：神经元 bHLH 因子和 Notch1 信号传导的作用。
影响因子：
14.9
作者：
Bhat, Kumar M. R.;Maddodi, Nityanand;Shashikant, Cooduvalli;Setaluri, Vijayasaradhi
通讯作者：
Setaluri, Vijayasaradhi