The impact of smoking and drinking on plasma levels of norharman
The impact of smoking and drinking on plasma levels of norharman
复制标题
吸烟和饮酒对诺哈曼血浆水平的影响
DOI：
10.1016/s0924-977x(01)00143-2
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发表时间：
2002
影响因子：
5.6
通讯作者：
D. Fekkes
中科院分区：
文献类型：
--
作者：
R. Spijkerman;R. Eijnden;D. Mheen;I. Bongers;D. Fekkes
β-咔啉norharman在药物依赖过程中的假设作用形成了对物质使用人群，特别是酗酒者和吸烟者中norharman血浆水平的几项研究的基础。然而，目前尚不清楚norharman是否涉及对这两种物质的依赖过程，或者只涉及烟草烟雾。在本研究中，测量了四组参与者的norharman血浆浓度，这四组参与者分别是过度饮酒或不饮酒的重度吸烟者和过度饮酒或不饮酒的非吸烟者。所有测量均在三个不同的日期进行，间隔为2个月，并在一天中进行三次，以考虑可能的昼夜节律或季节变化。结果表明，无论重度吸烟者的饮酒情况如何，诺哈曼血浆水平升高仅出现在重度吸烟者中。非吸烟过量饮酒者血浆norharman水平与对照组相似。研究结果表明，血浆中norharman水平的升高是由于大量吸烟，而不是过量饮酒。
The hypothesized role of the beta-carboline norharman in processes of drug dependence forms the basis for several studies on plasma levels of norharman among substance-using populations, particularly among alcoholics and smokers. However, it is not clear whether norharman is implicated in processes of dependence to both substances, or only to tobacco smoke. In the present study plasma concentrations of norharman were measured among four groups of participants regarding heavy smokers who do or do not drink alcohol excessively and nonsmokers who do or do not drink alcohol excessively. All measurements were conducted on three different days with an interval of 2 months in between and at three times during the day to account for possible circadian or seasonal variations. Results showed that elevated plasma levels of norharman appear only in heavy smokers regardless of their drinking profile. The norharman plasma levels of nonsmoking excessive drinkers showed a similar pattern to that of the control group. The findings indicate that elevated plasma levels of norharman are due to heavy smoking and not to excessive drinking.
影响因子：
5
作者：
GLICK, SD;ROSSMAN, K;CARLSON, JN
通讯作者：
CARLSON, JN
DOI：
10.1073/pnas.93.24.14065
发表时间：
1996-11-26
影响因子：
11.1
作者：
Fowler, JS;Volkow, ND;Wolf, AP
通讯作者：
Wolf, AP