Switching to a Standard Chow Diet at Weaning Improves the Effects of Maternal and Postnatal High-Fat and High-Sucrose Diet on Cardiometabolic Health in Adult Male Mouse Offspring.
Switching to a Standard Chow Diet at Weaning Improves the Effects of Maternal and Postnatal High-Fat and High-Sucrose Diet on Cardiometabolic Health in Adult Male Mouse Offspring.
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DOI：
10.3390/metabo12060563
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发表时间：
2022-06-18
期刊：
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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心肌线粒体功能障碍导致肥胖相关的心脏病。母体和产后饮食在心脏功能中起着重要作用，但产前和断奶饮食不匹配对心脏代谢功能的影响尚不清楚。我们测试了这样一种假设，即断奶后改用标准饮食将减轻与母体和出生后高脂肪/高蔗糖(HFHS)饮食相关的全身代谢障碍以及心脏和线粒体功能障碍。6个月大的雄性CD1后代来自饲喂HFHS饲料并断奶为相同HFHS饲料(HH)或转换为标准饮食(HC)的母鸡，与来自饲喂低脂肪/低蔗糖饲料并维持相同饮食(LL)的母鸡的后代进行比较。与HH相比，HC没有降低体重(BW)，但使糖耐量、血浆胆固醇、低密度脂蛋白和胰岛素水平正常化。由缩短率百分比表示的收缩功能不受饮食的影响。在新鲜分离的心肌线粒体中，在脂肪酸底物存在的情况下，HC的最大氧化磷酸化连接呼吸量和偶联效率显著高于LL和HH，并修改了与代谢和线粒体功能相关的基因。在断奶时改用标准饮食可以减轻长期服用HFHS对成年雄性小鼠后代的有害影响。
Cardiac mitochondrial dysfunction contributes to obesity-associated heart disease. Maternal and postnatal diet plays an important role in cardiac function, yet the impacts of a mismatch between prenatal and postweaning diet on cardiometabolic function are not well understood. We tested the hypothesis that switching to a standard chow diet after weaning would attenuate systemic metabolic disorders and cardiac and mitochondrial dysfunction associated with maternal and postnatal high-fat/high-sucrose (HFHS) diet in mice. Six-month-old male CD1 offspring from dams fed a HFHS diet and weaned to the same HFHS diet (HH) or switched to a standard chow diet (HC) were compared to offspring from dams fed a low-fat/low-sucrose diet and maintained on the same diet (LL). HC did not decrease body weight (BW) but normalized glucose tolerance, plasma cholesterol, LDL, and insulin levels compared to the HH. Systolic function indicated by the percent fractional shortening was not altered by diet. In freshly isolated cardiac mitochondria, maximal oxidative phosphorylation-linked respiratory capacity and coupling efficiency were significantly higher in the HC in the presence of fatty acid substrate compared to LL and HH, with modification of genes associated with metabolism and mitochondrial function. Switching to a standard chow diet at weaning can attenuate the deleterious effects of long-term HFHS in adult male mouse offspring.
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影响因子：
10.8
作者：
Chen, Le;Gong, Qizhi;Knowlton, Anne A.
通讯作者：
Knowlton, Anne A.
DOI：
10.1152/ajpheart.00013.2019
发表时间：
2019-05-01
影响因子：
4.8
作者：
Ferey, Jeremie L. A.;Boudoures, Anna L.;Moley, Kelle H.
通讯作者：
Moley, Kelle H.
影响因子：
3.5
作者：
Carbone, Salvatore;Mauro, Adolfo G.;Toldo, Stefano
通讯作者：
Toldo, Stefano
影响因子：
3.7
作者：
Matsui H;Yokoyama T;Sekiguchi K;Iijima D;Sunaga H;Maniwa M;Ueno M;Iso T;Arai M;Kurabayashi M
通讯作者：
Kurabayashi M
DOI：
10.1152/ajpgi.00172.2015
发表时间：
2015-10-01
期刊：
American journal of physiology. Gastrointestinal and liver physiology
影响因子：
--
作者：
Chassaing B;Miles-Brown J;Pellizzon M;Ulman E;Ricci M;Zhang L;Patterson AD;Vijay-Kumar M;Gewirtz AT
通讯作者：
Gewirtz AT