Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.

Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.
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DOI:
10.7150/ijbs.63721
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发表时间:
2022
影响因子:
9.2
通讯作者:
Kakar SS
Kakar SS
中科院分区:
生物学2区
文献类型:
--
作者:
Haldar S;Agrawal H;Saha S;Straughn AR;Roy P;Kakar SS

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促卵泡激素(FSH)及其受体(FSHR)已被报道负责几种生理功能和癌症。干细胞和癌症干细胞对FSH-FSHR系统的反应性使得FSH及其受体在癌症生物学背景下的功能更加有趣。本文综述了FSH-FSHR信号在正常生理、性腺干细胞、癌细胞中的作用,以及利用FSH-FSHR系统作为抗癌治疗靶点的潜在选择。
Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.
FSH对成年哺乳动物卵巢中干细胞的新作用诱导产后卵子发生和原始卵泡组件。
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