The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales.
The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales.
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DOI：
10.1016/j.cub.2018.03.051
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发表时间：
2018-05-21
期刊：
影响因子：
--
通讯作者：
Eichenbaum H
中科院分区：
文献类型：
--
作者：
Mau W;Sullivan DW;Kinsky NR;Hasselmo ME;Howard MW;Eichenbaum H
长期以来，人们一直假设，海马体的主要功能是发现和利用事件之间的时间关系。此前，有报道称，海马体中的时间细胞序列长达数十秒。其他研究表明，海马区的神经元放电会在数小时和数天内波动。这两种机制都可以在非常不同的时间尺度上对事件进行时间编码。然而，到目前为止，这两类现象从未被同时观察到，这是有必要将广泛的时间编码归因于海马体。在不受约束的小鼠身上使用活体钙成像，我们观察到了连接10 S延迟的海马神经元序列。在多天的时间里观察到了类似的序列，但参与这些序列的神经元集合逐渐改变。因此，在几秒钟内编码时间信息的同一群神经元也可以用来区分更长时间尺度上的时间段。这些结果统一了海马体中支持情节记忆的两个先前独立的时间处理范例。情节记忆跨越几秒、几分钟和几天的时间尺度。Mau等人。使用钙成像纵向监测海马区CA1区细胞序列。贝叶斯译码分析表明，相同的神经元群体在所有三个尺度上都携带着关于时间的信息。
It has long been hypothesized that a primary function of the hippocampus is to discover and exploit temporal relationships between events. Previously, it has been reported that sequences of “time cells” in the hippocampus extend for tens of seconds. Other studies have shown that neuronal firing in the hippocampus fluctuates over hours and days. Both of these mechanisms could enable temporal encoding of events over very different timescales. However, thus far, these two classes of phenomena have never been observed simultaneously, which is necessary to ascribe broad-range temporal coding to the hippocampus. Using in vivo calcium imaging in unrestrained mice, we observed sequences of hippocampal neurons that bridged a 10 s delay. Similar sequences were observed over multiple days, but the set of neurons participating in those sequences changed gradually. Thus, the same population of neurons that encodes temporal information over seconds can also be used to distinguish periods of time over much longer timescales. These results unify two previously separate paradigms of temporal processing in the hippocampus that support episodic memory. Episodic memories span timescales of seconds, minutes, and days. Mau et al. use calcium imaging to longitudinally monitor cell sequences in hippocampal CA1. Bayesian decoder analyses show that the same population of neurons carries information about time across all three scales.
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