Similarity breeds proximity: pattern similarity within and across contexts is related to later mnemonic judgments of temporal proximity.
Similarity breeds proximity: pattern similarity within and across contexts is related to later mnemonic judgments of temporal proximity.
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DOI：
10.1016/j.neuron.2014.01.042
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发表时间：
2014-03-05
期刊：
影响因子：
16.2
通讯作者：
Davachi L
中科院分区：
文献类型：
--
作者：
Ezzyat Y;Davachi L
随着时间的流逝，经验不断发展，但对支持时间扩展事件的相干情节记忆的机制知之甚少。动物的最新工作为海马中的信号提供了证据，这些信号可能会在时间差距之间链接事件，但是未知以及这种信号如何与后来的人类时间信息有关。我们测量了fMRI大胆活动的模式，因为人们编码了时间分开并操纵各个项目中共享或不同上下文的项目。我们发现，在上下文更改时，跨试验的大胆响应中的海马模式相似性预测了后来的时间记忆决策。相比之下，仅当上下文保持稳定时，枕叶皮层中的模式相似性才与内存有关。这些数据在人类中提供了第一个证据，即跨时间的海马中的代表性稳定性可能是时间记忆组织的一种机制。
Experiences unfold over time, but little is known about the mechanisms that support the formation of coherent episodic memories for temporally-extended events. Recent work in animals has provided evidence for signals in hippocampus that could link events across temporal gaps, however it is unknown whether and how such signals might be related to later memory for temporal information in humans. We measured patterns of fMRI BOLD activity as people encoded items that were separated in time and manipulated the presence of shared or distinct context across items. We found that hippocampal pattern similarity in the BOLD response across trials predicted later temporal memory decisions when context changed. By contrast, pattern similarity in lateral occipital cortex was related to memory only when context remained stable. These data provide the first evidence in humans that representational stability in hippocampus across time may be a mechanism for temporal memory organization.
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