Active DNA demethylation: many roads lead to Rome.
Active DNA demethylation: many roads lead to Rome.
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DOI：
10.1038/nrm2950
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发表时间：
2010-09
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影响因子：
--
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DNA甲基化是最具特征的表观遗传修饰之一，并且已经涉及许多生物学过程，包括转座因子沉默、基因组印记和X染色体失活。与其他表观遗传修饰相比，DNA甲基化被认为是相对稳定的。尽管DNA甲基化在长期沉默中起作用，但它比最初认为的更具动态性，因为在发育的特定阶段观察到了活跃的DNA去甲基化。在过去的十年中，许多酶被提出进行主动DNA去甲基化，越来越多的证据表明，根据上下文，这个过程可能是通过多种机制实现的。深入了解DNA甲基化是如何动态调节的，将拓宽我们对表观遗传调控的理解，并对体细胞重编程和再生医学产生重大影响。
DNA methylation is one of the best-characterized epigenetic modifications and has been implicated in numerous biological processes, including transposable element silencing, genomic imprinting and X chromosome inactivation. Compared with other epigenetic modifications, DNA methylation is thought to be relatively stable. Despite its role in long-term silencing, DNA methylation is more dynamic than originally thought as active DNA demethylation has been observed during specific stages of development. In the past decade, many enzymes have been proposed to carry out active DNA demethylation and growing evidence suggests that, depending on the context, this process may be achieved by multiple mechanisms. Insight into how DNA methylation is dynamically regulated will broaden our understanding of epigenetic regulation and have great implications in somatic cell reprogramming and regenerative medicine.
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DOI：
10.1016/s0006-291x(88)80489-3
发表时间：
1988-03-30
影响因子：
3.1
作者：
CANNON, SV;CUMMINGS, A;TEEBOR, GW
通讯作者：
TEEBOR, GW
影响因子：
3.5
作者：
Barton, SC;Arney, KL;Haaf, T
通讯作者：
Haaf, T
影响因子：
10.5
作者：
CARLSON, LL;PAGE, AW;BESTOR, TH
通讯作者：
BESTOR, TH
影响因子：
5.6
作者：
Boland, Michael J.;Christman, Judith K.
通讯作者：
Christman, Judith K.
影响因子：
4.8
作者：
Boorstein, RJ;Cummings, A;Teebor, GW
通讯作者：
Teebor, GW