The interferon response circuit: induction and suppression by pathogenic viruses.

The interferon response circuit: induction and suppression by pathogenic viruses.
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DOI:
10.1016/j.virol.2005.09.024
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发表时间:
2006-01-05
期刊:
影响因子:
3.7
通讯作者:
Weber F
Weber F
中科院分区:
医学3区
文献类型:
--
作者:
Haller O;Kochs G;Weber F

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I型干扰素(IFN-α/β)是潜在的抗病毒细胞因子和自适应免疫系统的调节剂。产生广泛的抗病毒蛋白和免疫活性细胞因子,反过来又进化了多种策略,以抵消IFN系统,否则我们会在这里讨论当前对病毒诱发的平衡行为的观点。 IFN反应和病毒反游戏。
Type I interferons (IFN-α/β) are potent antiviral cytokines and modulators of the adaptive immune system. They are induced by viral infection or by double-stranded RNA (dsRNA), a by-product of viral replication, and lead to the production of a broad range of antiviral proteins and immunoactive cytokines. Viruses, in turn, have evolved multiple strategies to counter the IFN system which would otherwise stop virus growth early in infection. Here we discuss the current view on the balancing act between virus-induced IFN responses and the viral counterplayers.
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