Utilizing patient perception of group treatment in exploring medication adherence, social support, and quality of life outcomes in people who inject drugs with hepatitis C.
Utilizing patient perception of group treatment in exploring medication adherence, social support, and quality of life outcomes in people who inject drugs with hepatitis C.
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DOI：
10.1016/j.jsat.2021.108459
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发表时间：
2021-07
影响因子：
3.9
通讯作者：
Litwin AH
中科院分区：
文献类型：
--
作者：
Howard KA;Rennert L;Pericot-Valverde I;Heo M;Norton BL;Akiyama MJ;Agyemang L;Litwin AH
注射毒品者(PWID)丙型肝炎病毒(丙型肝炎病毒)感染率很高。集体治疗是解决这一人群治疗障碍的一种实用选择。先前关于集体治疗的研究对其在解决治疗障碍方面的有效性得出了不同的结论。患者对群体环境的感知可能有助于解释这种差异。这项研究试图探索群体治疗环境指标与丙型肝炎病毒感染的PWID改善结果之间的关联。这是一项探索在PWID人群中治疗丙型肝炎的不同模式的随机对照试验的二次分析，由42名参与者组成，他们被随机分配到试验的治疗组分支。自变量包括参加的小组会议和小组气氛的参与、冲突和回避。因变量包括服药依从性、社会支持和与健康相关的生活质量。这项研究实施了通用的估计方程，以评估与治疗结束时结果的相关性。指示集体治疗环境的因素与服药依从性和其他影响丙型肝炎病毒感染的PWID的健康障碍有关：社会支持和健康相关的生活质量。冲突或回避的感觉与较差的结果有关，而出席会议的人数增加通常与较好的结果有关。这项研究证明了在治疗干预过程中检查群体环境因素的重要性。虽然是初步研究，但这项研究提供了丙型肝炎病毒感染的PWID治疗成功的具体指标，并对改善患者的健康结果和更好地为患者量身定做治疗提供了实际意义。
People who inject drugs (PWID) have a high prevalence of hepatitis C virus (HCV). Group treatment is a practical option for addressing barriers to treatment in this population. Prior research on group treatment has resulted in mixed conclusions about its effectiveness in addressing barriers to treatment. A patient’s perception of the group environment may help to explain this variability. This study sought to explore the association between indicators of group treatment environment and improved outcomes in HCV-infected PWID. This secondary analysis of a randomized controlled trial exploring different models of treatment for HCV in a PWID population consisted of 42 participants randomized to the group treatment branch of the trial. Independent variables consisted of group sessions attended and group climate constructs of engagement, conflict, and avoidance. Dependent variables consisted of medication adherence, social support, and health-related quality of life. The study implemented generalized estimating equations to assess associations with the outcomes at the end of treatment. Factors indicative of group treatment environment were related to medication adherence and other barriers to health for HCV-infected PWID: social support and health-related quality of life. Perceptions of conflict or avoidance were associated with worse outcomes, while increased session attendance was generally associated with better outcomes. The study attests to the importance of examining group environment factors during treatment interventions. Although preliminary, the study provides specific indicators of treatment success for HCV-infected PWID and practical implications to improve patients’ health outcomes and better tailor treatment to the patient.
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