Lysosome: The metabolic signaling hub.
Lysosome: The metabolic signaling hub.
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DOI：
10.1111/tra.12617
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Bar-Peled L
中科院分区：
文献类型：
--
作者：
Lamming DW;Bar-Peled L
在过去的五年里，溶酶体一直被认为是一个不起眼的细胞回收中心。这一概念在过去十年中经历了根本性转变，新的研究表明该细胞器是代谢信号通路的主要枢纽。掌握生长调节剂，包括蛋白激酶 mTOR（雷帕霉素的机械靶标）在溶酶体表面安家的发现，引起了人们对溶酶体在营养传感和细胞稳态中关键作用的浓厚兴趣。溶酶体维持和功能所需的转录网络刚刚被解开，它们与基于溶酶体的信号通路的联系也被揭示。汇聚在溶酶体上的分解代谢和合成代谢途径将该细胞器与细胞功能的多个方面连接起来。当这些途径失调时，它们会成为多种人类疾病的根源，并促进细胞和有机体的衰老。因此，了解基于溶酶体的信号通路如何发挥作用不仅将阐明这种细胞器的迷人生物学，而且对于释放其治疗潜力也至关重要。几十年来，溶酶体一直被认为是细胞回收中心，最近已成为代谢信号传导的中心枢纽。溶酶体的信号通路将这种细胞器与控制细胞代谢许多方面的关键合成代谢和分解代谢过程连接起来。溶酶体发出的代谢信号是多种人类疾病的促成因素，这强调了溶酶体作为调节人类健康的细胞位点的关键作用。
For the past five decades the lysosome has been characterized as an unglamorous cellular recycling center. This notion has undergone a radical shift in the last ten years, with new research revealing that this organelle serves as a major hub for metabolic signaling pathways. The discovery that master growth regulators, including the protein kinase mTOR (mechanistic Target Of Rapamycin) make their home at the lysosomal surface has generated intense interest in the lysosome’s key role in nutrient sensing and cellular homeostasis. The transcriptional networks required for lysosomal maintenance and function are just being unraveled and their connection to lysosome-based signaling pathways revealed. The catabolic and anabolic pathways that converge on the lysosome connect this organelle with multiple facets of cellular function; when these pathways are deregulated they underlie multiple human diseases, and promote cellular and organismal aging. Thus, understanding how lysosome-based signaling pathways function will not only illuminate the fascinating biology of this organelle but will also be critical in unlocking its therapeutic potentials. After decades of being known as just the cellular recycling center, the lysosome has recently emerged as a central hub for metabolic signaling. Signaling pathways that call the lysosome home connect this organelle to key anabolic and catabolic processes that control many facets of cellular metabolism. Metabolic signals emanating from the lysosome are contributors to multiple human diseases, emphasizing the key role of the lysosome as a cellular site for the regulation of human health.
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影响因子：
8.8
作者：
Chantranupong L;Wolfson RL;Orozco JM;Saxton RA;Scaria SM;Bar-Peled L;Spooner E;Isasa M;Gygi SP;Sabatini DM
通讯作者：
Sabatini DM
人类细胞中核能的系统分析揭示了选择性自噬期间旁观者的通量。
影响因子：
21.3
作者：
An H;Harper JW
通讯作者：
Harper JW
DOI：
10.1126/science.aag1417
发表时间：
2017-03-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Castellano BM;Thelen AM;Moldavski O;Feltes M;van der Welle RE;Mydock-McGrane L;Jiang X;van Eijkeren RJ;Davis OB;Louie SM;Perera RM;Covey DF;Nomura DK;Ory DS;Zoncu R
通讯作者：
Zoncu R
影响因子：
56.9
作者：
CHIANG, HL;TERLECKY, SR;DICE, JF
通讯作者：
DICE, JF
影响因子：
7.8
作者：
Baar EL;Carbajal KA;Ong IM;Lamming DW
通讯作者：
Lamming DW