Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.
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志贺氏菌种类的基因组动力学和多样性，杆菌痢疾的病因学剂。
DOI：
10.1093/nar/gki954
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发表时间：
2005
影响因子：
14.9
通讯作者：
Jin, Q
中科院分区：
文献类型：
--
作者：
Yang, F;Yang, J;Zhang, XB;Chen, LH;Jiang, Y;Yan, YL;Tang, XD;Wang, J;Xiong, ZH;Dong, J;Xue, Y;Zhu, YF;Xu, XY;Sun, LL;Chen, SX;Nie, H;Peng, JP;Xu, JG;Wang, Y;Yuan, ZH;Wen, YM;Yao, ZJ;Shen, Y;Qiang, BQ;Hou, YD;Yu, J;Jin, Q
志贺氏菌属细菌引起细菌性痢疾，这仍然是对公共卫生的重大威胁。属的地位和种的分类似乎不再有效，因为令人信服的证据表明，志贺氏菌，以及肠侵袭性大肠杆菌，来自大肠杆菌的多个来源，并形成一个单一的致病变种。尽管如此，志贺氏菌血清型1引起致命的流行病，但鲍氏志贺氏菌仅限于印度次大陆，而福氏志贺氏菌和宋内志贺氏菌分别在发展中国家和发达国家流行。为了开始在基因组水平上解释这些独特的流行病学和病理学特征，我们对四种代表性菌株进行了比较基因组学研究。志贺氏菌基因组中的每一个包括编码保守的主要毒力决定簇的毒力质粒。志贺氏菌染色体与大肠杆菌K12菌株MG 1655的染色体共享它们的大部分基因，但每个都有超过200个假基因，300 - 700个拷贝的插入序列（IS）元件，以及许多缺失，插入，易位和倒位。有广泛的多样性，推定的毒力基因，主要是通过噬菌体介导的横向基因转移获得。因此，通过涉及功能的获得和丧失的趋同进化，通过噬菌体介导的基因获得，IS介导的DNA重排和假基因的形成，志贺氏菌属物种。成为高度特异性的人类病原体，具有可变的流行病学和病理学特征。
The Shigella bacteria cause bacillary dysentery, which remains a significant threat to public health. The genus status and species classification appear no longer valid, as compelling evidence indicates that Shigella, as well as enteroinvasive Escherichia coli, are derived from multiple origins of E.coli and form a single pathovar. Nevertheless, Shigella dysenteriae serotype 1 causes deadly epidemics but Shigella boydii is restricted to the Indian subcontinent, while Shigella flexneri and Shigella sonnei are prevalent in developing and developed countries respectively. To begin to explain these distinctive epidemiological and pathological features at the genome level, we have carried out comparative genomics on four representative strains. Each of the Shigella genomes includes a virulence plasmid that encodes conserved primary virulence determinants. The Shigella chromosomes share most of their genes with that of E.coli K12 strain MG1655, but each has over 200 pseudogenes, 300∼700 copies of insertion sequence (IS) elements, and numerous deletions, insertions, translocations and inversions. There is extensive diversity of putative virulence genes, mostly acquired via bacteriophage-mediated lateral gene transfer. Hence, via convergent evolution involving gain and loss of functions, through bacteriophage-mediated gene acquisition, IS-mediated DNA rearrangements and formation of pseudogenes, the Shigella spp. became highly specific human pathogens with variable epidemiological and pathological features.
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影响因子：
10.7
作者：
Escobar-Páramo, P;Clermont, O;Denamur, E
通讯作者：
Denamur, E
影响因子：
3.1
作者：
Lan, R;Alles, MC;Reeves, PR
通讯作者：
Reeves, PR
影响因子：
3.1
作者：
Lan, RT;Stevenson, G;Reeves, PR
通讯作者：
Reeves, PR
影响因子：
3.1
作者：
FONTAINE, A;ARONDEL, J;SANSONETTI, PJ
通讯作者：
SANSONETTI, PJ
DOI：
10.1073/pnas.95.7.3943
发表时间：
1998-03-31
影响因子：
11.1
作者：
Maurelli, AT;Fernández, RE;Fasano, A
通讯作者：
Fasano, A