Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank.
Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank.
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DOI：
10.1016/j.joca.2021.08.002
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发表时间：
2021-11
影响因子：
7
通讯作者：
Tobias JH
中科院分区：
文献类型：
--
作者：
Faber BG;Ebsim R;Saunders FR;Frysz M;Gregory JS;Aspden RM;Harvey NC;Davey Smith G;Cootes T;Lindner C;Tobias JH
为了研究髋臼发育不良(AD)、凸轮和/或钳形结构是否与英国生物银行(UKB)的放射学髋关节骨关节炎(RhoA)和髋关节疼痛相关，如果是，观察骨赘的分布情况。来自UKB的受试者接受左髋部双能X线骨密度仪(DXA)扫描，自动计算出α角(AA)、外侧中心缘角(LCEA)和关节间隙狭窄(JSN)。用AA和LCEA定义凸轮和钳形的形态和AD。手动测量骨赘，并根据JSN和骨赘测量计算RhoA分级。采用Logistic回归分析这些髋关节形态与RhoA、骨赘、JSN和髋关节疼痛之间的关系。6,807人(平均年龄：62.7岁；3382/3425名男性/女性)。CAM形态在男性高于女性(分别为15.4%和1.8%)。在男性中，凸轮形态与RhoA[OR 3.20(95%CI 2.41-4.25)]、JSN[1.53(1.24-1.88)]、髋臼[1.87(1.48-2.36)]、股骨上[1.94(1.45-2.57)]和下[4.75(3.44-6.57)]骨赘和髋关节疼痛[1.48(1.05-2.09)]相关。在女性中也发现了大致相似的关联，但统计证据较弱。钳子形态和AD与RhoA或髋关节疼痛均无关联。CAM形态主要见于男性，在男性中与RhoA和髋关节疼痛相关。在男性和女性中，凸轮形态与股骨头下部骨赘的相关性比股骨头上方和髋臼的骨赘更强。进一步的研究证明了与凸轮形态相关的生物力学紊乱的特征，这是观察到的骨赘分布的基础。
To examine whether acetabular dysplasia (AD), cam and/or pincer morphology are associated with radiographic hip osteoarthritis (rHOA) and hip pain in UK Biobank (UKB) and, if so, what distribution of osteophytes is observed. Participants from UKB with a left hip dual-energy X-ray absorptiometry (DXA) scan had alpha angle (AA), lateral centre-edge angle (LCEA) and joint space narrowing (JSN) derived automatically. Cam and pincer morphology, and AD were defined using AA and LCEA. Osteophytes were measured manually and rHOA grades were calculated from JSN and osteophyte measures. Logistic regression was used to examine the relationships between these hip morphologies and rHOA, osteophytes, JSN, and hip pain. 6,807 individuals were selected (mean age: 62.7; 3382/3425 males/females). Cam morphology was more prevalent in males than females (15.4% and 1.8% respectively). In males, cam morphology was associated with rHOA [OR 3.20 (95% CI 2.41–4.25)], JSN [1.53 (1.24–1.88)], and acetabular [1.87 (1.48–2.36)], superior [1.94 (1.45–2.57)] and inferior [4.75 (3.44–6.57)] femoral osteophytes, and hip pain [1.48 (1.05–2.09)]. Broadly similar associations were seen in females, but with weaker statistical evidence. Neither pincer morphology nor AD showed any associations with rHOA or hip pain. Cam morphology was predominantly seen in males in whom it was associated with rHOA and hip pain. In males and females, cam morphology was associated with inferior femoral head osteophytes more strongly than those at the superior femoral head and acetabulum. Further studies are justified to characterise the biomechanical disturbances associated with cam morphology, underlying the observed osteophyte distribution.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
7
作者：
Hartley, A.;Hardcastle, S. A.;Gregson, C. L.
通讯作者：
Gregson, C. L.
影响因子：
5.3
作者：
Gosvig, Kasper Kjaerulf;Jacobsen, Steffen;Troelsen, Anders
通讯作者：
Troelsen, Anders
DOI：
10.1097/01.blo.0000096804.78689.c2
发表时间：
2003-12-01
影响因子：
4.2
作者：
Ganz, R;Parvizi, J;Siebenrock, KA
通讯作者：
Siebenrock, KA
影响因子：
2.3
作者：
Hunter, David J.;McDougall, Jason J.;Keefe, Francis J.
通讯作者：
Keefe, Francis J.