Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone.
Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone.
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DOI：
10.1371/journal.pone.0083977
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Murohara T
中科院分区：
文献类型：
--
作者：
Inaba H;Takeshita K;Uchida Y;Hayashi M;Okumura T;Hirashiki A;Yoshikawa D;Ishii H;Yamamoto K;Nakayama T;Hirayama M;Matsumoto H;Matsushita T;Murohara T
在血流介导的扩张（FMD）的重复测量中，测量间隔的持续时间仍然存在争议。在这项初步研究中，我们进行了三个连续测量低流量介导的收缩（L-FMC），FMD和流量介导的总扩张（FMTD; L-FMC+ FMD）在基线和间隔15和60分钟在30名健康男性。FMD 15、L-FMC 15和FMTD 15显著低于各自的首次测量值，但所有受试者的所有指标均显示在60分钟时完全恢复。15 min时基线直径略有增加，60 min时恢复，但最大直径、基线流速和反应流速不变。我们研究了15分钟FMTD恢复率（FMTD-R）和心踝血管指数（CAVI）之间的关系。单因素分析显示，FMTD-R与CAVI和L-FMC 0中度相关。根据FMTD-R值对患者进行分组;低FMTD-R组[低于中位数（−26.2%）]的吸烟者比例和CAVI值显著高于高FMTD-R组。在另一组25名健康受试者中评价了FMTD和FMTD-R的重现性。FMTD和FMTD-R的测量变异范围分别为1.1%和4.6%，组内相关系数分别为0.93和0.95。本研究表明，钝恢复FMD在15分钟内，这表明需要选择一个更充分的测量之间的间隔，以避免低估FMD在随后的测量。结果表明，FMTD-R和FMTD测量的可重复性，FMTD-R可能参与健康受试者的动脉硬化和早期血管损伤。
In repetitive measurements of flow-mediated dilatation (FMD), the duration of the interval between measurements remains controversial. In this pilot study, we conducted three sequential measurements of low–flow-mediated constriction (L-FMC), FMD and flow-mediated total dilation (FMTD; L-FMC+ FMD) at baseline and intervals of 15 and 60 min in 30 healthy males. FMD15, L-FMC15, and FMTD15 were significantly lower than the respective first measurements, but all indices showed full recovery at 60 min in all subjects. The baseline diameter was slightly increased at 15 min and restored at 60 min, but the maximum diameter, and the baseline and reactive flow velocity unchanged. We examined the relationship between recovery rate of FMTD at 15 min (FMTD-R) and cardio-ankle vascular index (CAVI). Univariate analysis showed moderate correlation between FMTD-R, and CAVI and L-FMC0. Patients were divided according to FMTD-R value; the low-FMTD-R group [below the median value (−26.2%)] included a significantly higher proportion of smokers and higher CAVI values than the high-FMTD-R group. The reproducibility of FMTD and FMTD-R was evaluated in another group of 25 healthy subjects. The range of variation across measurements was 1.1% for FMTD and 4.6% for FMTD-R; with intraclass correlation coefficients of 0.93 and 0.95, respectively. The present study demonstrated blunted recovery of FMD within 15 min, suggesting the need for selection of a more adequate interval between measurements to avoid underestimation of FMD in subsequent measurements. The findings demonstrated the reproducibility of FMTD-R and FMTD measurements, and that FMTD-R might be involved in arterial stiffness and early vascular impairment in the healthy subjects.
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影响因子：
3.7
作者：
Rakobowchuk M;Parsloe ER;Gibbins SE;Harris E;Birch KM
通讯作者：
Birch KM
影响因子：
5.3
作者：
Koivistoinen, Teemu;Virtanen, Marko;Kahonen, Mika
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Kahonen, Mika
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8.3
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Harris, Ryan A.;Nishiyama, Steven K.;Richardson, Russell S.
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Richardson, Russell S.
影响因子：
39.3
作者：
Gori, Tommaso;Muxel, Selina;Muenzel, Thomas
通讯作者：
Muenzel, Thomas
影响因子：
4.1
作者：
Vásquez-Vivar, J;Martásek, P;Kalyanaraman, B
通讯作者：
Kalyanaraman, B