The contributions of cancer cell metabolism to metastasis.
The contributions of cancer cell metabolism to metastasis.
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DOI：
10.1242/dmm.032920
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发表时间：
2018-05-03
影响因子：
4.3
通讯作者：
Benitah SA
中科院分区：
文献类型：
--
作者：
Pascual G;Domínguez D;Benitah SA
转移仍然是全球癌症相关死亡的主要原因，我们无法识别在远处定植的肿瘤细胞，这阻碍了有效的抗转移治疗的发展。然而，随着最近的研究进展，我们开始区分启动转移的细胞和它们的非转移对应细胞。重要的是，基因组测序的进展表明，转移能力的获得不涉及驱动突变的逐渐积累；此外，在肿瘤发生的早期阶段，癌细胞含有赋予它们转移能力的驱动突变组合。新的发现突出表明，细胞可以在原发肿瘤生长的早期扩散到远处，在转移之前保持休眠和长时间无法治疗。因此，转移细胞必须需要局部和全身的影响才能产生转移。这一假设表明，源自我们生活方式的因素，如我们的饮食，对肿瘤的发展产生了强烈的影响，如果了解这些因素，这些因素是可以调节的。在这里，我们总结了关于特定代谢信号如何调节转移细胞的行为以及它们如何影响转移细胞的基因组和表观基因组的最新发现。我们还讨论了如何利用代谢和表观基因组之间的串扰来开发新的抗转移疗法。摘要：在这篇综述中，作者总结了关于特定代谢信号如何调节和影响转移性癌细胞的行为、基因组和表观基因组的最新发现。他们还讨论了如何利用新陈代谢和转移细胞的表观基因组之间的串扰来开发新的抗转移疗法。
Metastasis remains the leading cause of cancer-related deaths worldwide, and our inability to identify the tumour cells that colonize distant sites hampers the development of effective anti-metastatic therapies. However, with recent research advances we are beginning to distinguish metastasis-initiating cells from their non-metastatic counterparts. Importantly, advances in genome sequencing indicate that the acquisition of metastatic competency does not involve the progressive accumulation of driver mutations; moreover, in the early stages of tumorigenesis, cancer cells harbour combinations of driver mutations that endow them with metastatic competency. Novel findings highlight that cells can disseminate to distant sites early during primary tumour growth, remaining dormant and untreatable for long periods before metastasizing. Thus, metastatic cells must require local and systemic influences to generate metastases. This hypothesis suggests that factors derived from our lifestyle, such as our diet, exert a strong influence on tumour progression, and that such factors could be modulated if understood. Here, we summarize the recent findings on how specific metabolic cues modulate the behaviour of metastatic cells and how they influence the genome and epigenome of metastatic cells. We also discuss how crosstalk between metabolism and the epigenome can be harnessed to develop new anti-metastatic therapies. Summary: In this Review the authors summarize recent findings on how specific metabolic cues modulate and influence the behaviour, genome and epigenome of metastatic cancer cells. They also discuss how the crosstalk between metabolism and the epigenome of metastatic cells can be harnessed to develop new anti-metastatic therapies.
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影响因子：
16
作者：
Charlet J;Duymich CE;Lay FD;Mundbjerg K;Dalsgaard Sørensen K;Liang G;Jones PA
通讯作者：
Jones PA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
影响因子：
4.3
作者：
Baenke F;Peck B;Miess H;Schulze A
通讯作者：
Schulze A
影响因子：
4.3
作者：
Bonuccelli, Gloria;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.