Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.
Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder.
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DOI：
10.1016/j.jad.2015.12.071
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发表时间：
2016-03-15
影响因子：
6.6
通讯作者：
O'Neill J
中科院分区：
文献类型：
--
作者：
Armstrong CC;Moody TD;Feusner JD;McCracken JT;Chang S;Levitt JG;Piacentini JC;O'Neill J
功能磁共振成像图理论揭示了静息态大脑网络，但从未用于儿童强迫症。全脑静息态fMRI采集自21名强迫症儿童和20名年龄匹配的健康对照。BOLD连通性进行了分析，产生全局和局部图论指标在100个孩子为基础的功能节点。我们还比较了额极、辅助运动和感觉运动皮层的局部指标，这些区域与最近的神经成像和/或脑刺激治疗强迫症的研究有关。与成人一样，患者的整体度量小世界性显著（P<0.05）低于对照组，低13.5%（%平均差异= 100%×（OCD平均值-对照组平均值）/对照组平均值）。这表明患者的信息传递效率较低。此外，模块性在强迫症中较低（15.1%，P<0.01），表明较少颗粒-或不同组织-功能性脑包裹。在额极、辅助运动、感觉运动和皮层中观察到较高的聚类系数（23.9- 32.4%，P<0.05），而在一个额极部位中介数中心性较低（-63.6%，P <0.01）。这些发现与这些部位的局部密集连接或与其他大脑区域的互动较少一致。相对较大的淋巴结大小;相对较小的样本量，部分患者存在合并症。与健康儿童相比，儿童强迫症患者表现出异常的全局和局部静息态网络连接拓扑结构。局部结果雅阁最近的观点强迫症作为一种障碍与感觉运动成分。
fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. Whole-brain resting-state fMRI was acquired at 3 T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD. As in adults, the global metric small-worldness was significantly (P<0.05) lower in patients than controls, by 13.5% (%mean difference = 100%×(OCD mean – control mean)/control mean). This suggests less efficient information transfer in patients. In addition, modularity was lower in OCD (15.1%, P<0.01), suggesting less granular-- or differently organized-- functional brain parcellation. Higher clustering coefficients (23.9-32.4%, P<0.05) were observed in patients in frontopolar, supplementary motor, sensorimotor, and cortices with lower betweenness centrality (-63.6%, P<0.01) at one frontopolar site. These findings are consistent with more locally intensive connectivity or less interaction with other brain regions at these sites. Relatively large node size; relatively small sample size, comorbidities in some patients. Pediatric OCD patients demonstrate aberrant global and local resting-state network connectivity topologies compared to healthy children. Local results accord with recent views of OCD as a disorder with sensorimotor component.
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影响因子：
3.7
作者：
Humphries MD;Gurney K
通讯作者：
Gurney K
DOI：
10.1080/13825580600966383
发表时间：
2007-01-01
影响因子：
2.2
作者：
Chang, Susanna W.;McCracken, James T.;Piacentini, John C.
通讯作者：
Piacentini, John C.
影响因子：
25.8
作者：
Beucke, Jan C.;Sepulcre, Jorge;Kathmann, Norbert
通讯作者：
Kathmann, Norbert
DOI：
10.1523/jneurosci.2308-09.2009
发表时间：
2009-12-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gong G;Rosa-Neto P;Carbonell F;Chen ZJ;He Y;Evans AC
通讯作者：
Evans AC
影响因子：
5.7
作者：
Braun, Urs;Plichta, Michael M.;Meyer-Lindenberg, Andreas
通讯作者：
Meyer-Lindenberg, Andreas