GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.
GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.
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DOI：
10.1016/j.resp.2018.02.009
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发表时间：
2018-11
影响因子：
2.3
通讯作者：
Poliacek I
中科院分区：
文献类型：
--
作者：
Kotmanova Z;Simera M;Veternik M;Martvon L;Misek J;Jakus J;Shen TY;Musselwhite MN;Pitts T;Bolser DC;Poliacek I
将GABA、muscimol和巴氯芬微量注射到24只麻醉猫的吻侧（rNTS）和尾侧孤立束核（cNTS）中。记录并分析膈肌（DIA）、腹肌（ABD）肌电图（emg）、血压、食管压（EP）。双侧微注射1 mM GABA（共66±4 nl）、1 mM巴氯芬（64±4 nl）和单侧微注射0.5 mM muscimol（33±1 nl）可显著降低咳嗽次数（CN）、ABD肌电图振幅、呼气EP，延长咳嗽吸气期持续时间。微量注射GABA可降低咳嗽相关DIA肌电图和吸气EP的振幅；显微注射muscimol可降低对侧咳嗽DIA肌电图。只有微量注射GABA到cNTS中才能抑制CN。在某些情况下，显微注射延长了吸气期，降低了呼吸频率，改变了呼吸深度，增加了血压和心率。我们的研究结果证实，rNTS中的gaba能抑制机制可以调节麻醉猫的咳嗽。
GABA, muscimol, and baclofen were microinjected into the rostral (rNTS) and caudal solitary tract nucleus (cNTS) in 24 anesthetized cats. Electromyograms (EMGs) of diaphragm (DIA) and abdominal muscles (ABD), blood pressure and esophageal pressure (EP) were recorded and analysed. Bilateral microinjections of 1 mM GABA (total 66 ± 4 nl), 1 mM baclofen (64 ± 4 nl) and unilateral microinjections of 0.5 mM muscimol (33 ± 1 nl) in the rNTS significantly reduced cough number (CN), amplitudes of ABD EMGs, expiratory EP, and prolonged the duration of the cough inspiratory phase. GABA microinjections decreased the amplitudes of cough-related DIA EMGs and inspiratory EP; muscimol microinjections decreased the cough DIA EMG on the contralateral side. Only microinjections of GABA into the cNTS suppressed CN. In some cases, microinjections prolonged the inspiratory phase, lowered respiratory rate, changed the depth of breathing, and increased blood pressure and heart rate. Our results confirm that GABA-ergic inhibitory mechanisms in the rNTS can regulate coughing in the anesthetized cat.
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影响因子：
3.4
作者：
Marchenko, Vitaliy;Koizumi, Hidehiko;Smith, Jeffrey C.
通讯作者：
Smith, Jeffrey C.
DOI：
10.1152/ajpregu.00184.2008
发表时间：
2008-07-01
影响因子：
2.8
作者：
Mutolo, Donatella;Bongianni, Fulvia;Pantaleo, Tito
通讯作者：
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影响因子：
2.5
作者：
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通讯作者：
Paton, JFR
影响因子：
2.5
作者：
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通讯作者：
Travagli, R. Alberto
影响因子：
3.8
作者：
Mutolo, Donatella;Bongianni, Fulvia;Pantaleo, Tito
通讯作者：
Pantaleo, Tito