The role of dopamine in intracranial self-stimulation of the ventral tegmental area
The role of dopamine in intracranial self-stimulation of the ventral tegmental area
复制标题
多巴胺在腹侧被盖区颅内自我刺激中的作用
DOI：
10.1523/jneurosci.07-12-03888.1987
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
AG Phillips
中科院分区：
文献类型：
--
作者：
H. Fibiger;FG LePiane;A. Jakubovic;AG Phillips
本实验研究了多巴胺(DA)能神经元在电刺激大鼠腹侧被盖区(VTA)产生的脑刺激奖赏中的作用。在第一个实验中，广泛的6-羟基多巴胺损毁中脑DA投射的上行纤维，当损毁与刺激电极同侧时，导致颅内自刺激(ICS)率电流强度函数的显著变化。类似的对侧损伤对这些功能没有影响，因此排除了损伤导致的功能缺陷是损伤后广泛电流强度范围内ICS比率下降的原因。在第二个实验中，从VTA内电极获得的ICS导致刺激电极同侧纹状体、伏隔核和嗅结节中DA代谢产物3，4-二羟基苯乙酸(DOPAC)和高香草酸(HVA)的显著增加。被认为是DA利用指标的DOPAC和HVA/DA的比值在电极同侧的这些脑区也有所增加。对侧纹状体、伏隔核和嗅结节无明显变化。在以相同的速度和电流接受大脑刺激但没有杠杆按压刺激的受刺激的“带轭”动物中，也观察到了类似的增加。第三个实验考察了杠杆压榨食物对纹状体、伏隔核和嗅结节中DA利用的影响。尽管有很高的应答率，但这些脑区的DOPAC：DA或HVA：DA比率没有观察到任何影响。
The role of dopaminergic (DA) neurons in brain stimulation reward produced by electrical stimulation of the ventral tegmental area (VTA) was investigated in the rat. In the first experiment, extensive 6- hydroxydopamine lesions of the ascending fibers of the mesotelencephalic DA projections resulted in significant changes in intracranial self-stimulation (ICS) rate-current intensity functions when the lesion was ipsilateral to the stimulating electrode. Similar contralateral lesions had no effect on these functions, thus ruling out lesion-induced performance deficits as being responsible for the decreases in ICS rates across the wide range of current intensities that occurred after the ipsilateral lesions. In the second experiment, ICS obtained from electrodes in the VTA resulted in significant increases in the DA metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum, nucleus accumbens, and olfactory tubercle ipsilateral to the stimulating electrode. The ratios of DOPAC and HVA to DA, considered to be indices of DA utilization, were also increased in these brain regions ipsilateral to the electrode. No changes were observed in the contralateral striatum, nucleus accumbens, and olfactory tubercle. Similar increases were observed in stimulated “yoked” animals that received brain stimulation at identical rates and currents but did not lever-press for this stimulation. The third experiment examined the effects of lever- pressing for food on an FR8 schedule of reinforcement on DA utilization in the striatum, nucleus accumbens, and olfactory tubercle. Despite high rates of responding, no effects were observed on DOPAC:DA or HVA:DA ratios in these brain regions.
下丘脑奖励机制：两个具有胆碱能成分的第一阶段纤维群。
DOI：
10.1126/science.2981439
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gratton,A;Wise,RA
通讯作者：
Wise,RA
麻醉剂和电刺激对黑质纹状体多巴胺能神经元的影响。
DOI：
--
发表时间：
1983
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
McCown,TJ;Mueller,RA;Breese,GR
通讯作者：
Breese,GR