Prolonged salivary cortisol recovery in second-trimester pregnant women and attenuated salivary alpha-amylase responses to psychosocial stress in human pregnancy.
Prolonged salivary cortisol recovery in second-trimester pregnant women and attenuated salivary alpha-amylase responses to psychosocial stress in human pregnancy.
复制标题
妊娠中期孕妇唾液皮质醇恢复时间延长，唾液α-淀粉酶对人类妊娠社会心理压力的反应减弱。
DOI：
10.1210/jc.2005-1816
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
U. Ehlert
中科院分区：
文献类型：
--
作者：
A. Nierop;Aliki Bratsikas;Ariadne Klinkenberg;U. Nater;R. Zimmermann;U. Ehlert
上下文
人类压力相关妊娠并发症的潜在生物学机制仍然知之甚少。最近对孕妇的药理学或物理激发程序的研究导致了不均匀的结果。此外，迄今为止还没有进行过任何研究，在怀孕的不同阶段使用心理社会压力范式。
目的
本研究的目的是确定内分泌，自主神经和心理反应标准化的心理社会压力在不同阶段的怀孕。
设计
90名健康女性（年龄21-37岁），包括30名妊娠中期开始的女性和30名妊娠晚期开始的女性，以及30名处于月经周期卵泡期的非妊娠女性，进行了心理社会应激试验。反复测量唾液游离皮质醇、α-淀粉酶、心率和心理参数。
结果
唾液皮质醇恢复显着延长中期妊娠妇女（P = 0.04）。皮质醇和心率增加的两个怀孕组被证明是与对照组。与非妊娠妇女相比，两个妊娠组的α-淀粉酶升高明显减弱（P = 0.008）。
结论
从这些数据中，我们得出结论，与大鼠妊娠相反，女性妊娠不会导致下丘脑-垂体-肾上腺轴对心理社会应激的抑制。此外，衰减的α-淀粉酶应激反应可能反映了怀孕期间自主神经系统内的保护过程，而中期妊娠开始时皮质醇恢复时间延长可能与这段时间内易受应激相关妊娠并发症的影响有关。
CONTEXT
The underlying biological mechanisms of stress-related pregnancy complications in humans are still poorly understood. Recent research on pharmacological or physical provocation procedures in pregnant women has resulted in inhomogeneous findings. Furthermore, no studies conducted so far have used a psychosocial stress paradigm at different stages of pregnancy.
OBJECTIVE
The aim of this study was to identify endocrine, autonomic, and psychological responses to standardized psychosocial stress at different stages of pregnancy.
DESIGN
Ninety healthy women (aged 21-37 yr), including 30 pregnant women at the beginning of the second trimester and 30 women at the beginning of the third trimester, as well as 30 nonpregnant women in the follicular phase of their menstrual cycle, underwent a psychosocial stress test. Salivary free cortisol, alpha-amylase, heart rate, and psychological parameters were repeatedly measured.
RESULTS
Salivary cortisol recovery was significantly prolonged in second-trimester pregnant women (P = 0.04). Cortisol and heart rate increases of both pregnant groups were shown to be comparable with those of the controls. alpha-Amylase increases of both pregnant groups were markedly attenuated compared with nonpregnant women (P = 0.008).
CONCLUSIONS
From these data, we conclude that, in contrast to pregnancy in rats, pregnancy in women does not result in a restraint of the hypothalamic-pituitary-adrenal axis to psychosocial stress. Furthermore, attenuated alpha-amylase stress response might reflect protective processes within the autonomic nervous system during pregnancy, whereas prolonged cortisol recovery during the beginning of second-trimester pregnancy might be associated with the vulnerability to stress-related pregnancy complications during this period of time.
影响因子：
4.7
作者：
Earle, TL;Linden, W;Wenberg, J
通讯作者：
Wenberg, J
影响因子：
9.8
作者：
Wadhwa, PD;Garite, TJ;Sandman, CA
通讯作者：
Sandman, CA
影响因子：
9.8
作者：
Glynn, LM;Wadhwa, PD;Sandman, CA
通讯作者：
Sandman, CA