Predictors of esophageal varices and first variceal bleeding in liver cirrhosis patients.
Predictors of esophageal varices and first variceal bleeding in liver cirrhosis patients.
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DOI：
10.3748/wjg.v23.i26.4806
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发表时间：
2017-07-14
影响因子：
4.3
通讯作者：
Burazeri G
中科院分区：
文献类型：
--
作者：
Kraja B;Mone I;Akshija I;Koçollari A;Prifti S;Burazeri G
使用非侵入性标记物评估阿尔巴尼亚诊断为肝硬变患者的食道静脉曲张(EV)和静脉曲张出血的“预测因素”。139例新诊断的无静脉曲张破裂出血的肝硬变患者被纳入本研究。测定所有受试者的终末期肝病模型(MELD)、谷草转氨酶/丙氨酸氨基转移酶比值(AST/ALT)、谷草转氨酶/血小板比率指数(APRI)、血小板计数/脾直径(PC/SD)、fiBroSis-4指数(FIB4)、肝纤维化指数(FI)和金氏评分。所有患者在入院后两天内接受了内窥镜检查。主要终点为首次食道静脉曲张出血(EVB)事件。对EV和EVB存在的“预测指标”的诊断性能通过从接受者操作特征程序中获得的敏感度和特异度来评估。FIB-4是唯一强有力且有意义的食道静脉曲张的“预测因子”(多变量调整后的OR=1.57，每增加一个单位；95%CI：1.15-2.14)。此外，FIB-4的临界值3.23是预测食道静脉曲张的重要指标，其敏感性为72%，特异性为58%，曲线下面积比例为66%(P=0.01)。在随访期间(中位数：31.5个月；四分位数范围：11-59个月)，34名患者(24%)经历了第一次EVB。FIB-4对EVB的预测作用较差(AUC仅为51%)，其临界值为5.02。AST/ALT、APRI、PC/SD、FI、MELD、King‘s评分的AUC在45%~55%之间。没有一种非侵入性标记物被证明是预测EVB的有用指标。尽管诊断准确率较低，但FIB-4仍是最有效的非侵入性肝纤维化标志物，可作为肝硬变患者的初始筛查工具。
To assess “predictors” of esophageal varices (EV) and variceal bleeding using non-invasive markers in Albanian patients diagnosed with liver cirrhosis. One hundred thirty-nine newly diagnosed cirrhotic patients without variceal bleeding were included in this analysis. Model for end-stage liver disease (MELD), aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT), AST to platelet ratio index (APRI), platelet count to spleen diameter (PC/SD), fibrosis-4-index (FIB-4), fibrosis index (FI) and King’s Score were measured for all participants. All patients underwent endoscopic assessment within two days of hospitalization. The major end point was the first esophageal variceal bleeding (EVB) event. The diagnostic performance of “predictors” for the presence of EV and EVB were assessed by sensitivity and specificity values obtained from the receiver operating characteristics procedure. FIB-4 was the only strong and significant “predictor” of esophageal varices (multivariable-adjusted OR = 1.57 for one unit increment; 95%CI: 1.15-2.14). Furthermore, a cut-off value of 3.23 for FIB-4 was a significant predictor of esophageal varices, with a sensitivity of 72%, a specificity of 58% and a proportion of area under the curve (AUC) of 66% (P = 0.01). During the follow-up (median: 31.5 mo; interquartile range: 11-59 mo), 34 patients (24%) experienced a first EVB. FIB-4 was a poor predictor of EVB (the AUC was only 51%) for a cut-off value of 5.02. Furthermore, the AUC of AST/ALT, APRI, PC/SD, FI, MELD and King's Score ranged from 45% to 55%. None of the non-invasive markers turned out to be a useful predictor of EVB. Despite the low diagnostic accuracy, FIB-4 appears the most efficient non-invasive liver fibrosis marker which can be used as an initial screening tool for cirrhotic patients.
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影响因子：
168.9
作者：
Naghavi, Mohsen;Wang, Haidong;Lozano, Rafael;Davis, Adrian;Liang, Xiaofeng;Zhou, Maigeng;Vollset, Stein Emil;Ozgoren, Ayse Abbasoglu;Abdalla, Safa;Abd-Allah, Foad;Aziz, Muna I. Abdel;Abera, Semaw Ferede;Aboyans, Victor;Abraham, Biju;Abraham, Jerry P.;Abuabara, Katrina E.;Abubakar, Ibrahim;Abu-Raddad, Laith J.;Abu-Rmeileh, Niveen M. E.;Achoki, Tom;Adelekan, Ademola;Ademi, Zanfi Na;Adofo, Koranteng;Adou, Arsene Kouablan;Adsuar, Jose C.;Arnlov, Johan;Agardh, Emilie Elisabet;Akena, Dickens;Al Khabouri, Mazin J.;Alasfoor, Deena;Albittar, Mohammed;Alegretti, Miguel Angel;Aleman, Alicia V.;Alemu, Zewdie Aderaw;Alfonso-Cristancho, Rafael;Alhabib, Samia;Ali, Mohammed K.;Ali, Raghib;Alla, Francois;Al Lami, Faris;Allebeck, Peter;AlMazroa, Mohammad A.;Salman, Rustam Al-Shahi;Alsharif, Ubai;Alvarez, Elena;Alviz-Guzman, Nelson;Amankwaa, Adansi A.;Amare, Azmeraw T.;Ameli, Omid;Amini, Hassan;Ammar, Walid;Anderson, H. Ross;Anderson, Benjamin O.;Antonio, Carl Abelardo T.;Anwari, Palwasha;Apfel, Henry;Cunningham, Solveig Argeseanu;Arsenijevic, Valentina S. Arsic;Al Artaman;Asad, Majed Masoud;Asghar, Rana J.;Assadi, Reza;Atkins, Lydia S.;Atkinson, Charles;Badawi, Alaa;Bahit, Maria C.;Bakfalouni, Talal;Balakrishnan, Kalpana;Balalla, Shivanthi;Banerjee, Amitava;Barber, Ryan M.;Barker-Collo, Suzanne L.;Barquera, Simon;Barregard, Lars;Barrero, Lope H.;Barrientos-Gutierrez, Tonatiuh;Basu, Arindam;Basu, Sanjay;Basulaiman, Mohammed Omar;Beardsley, Justin;Bedi, Neeraj;Beghi, Ettore;Bekele, Tolesa;Bell, Michelle L.;Benjet, Corina;Bennett, Derrick A.;Bensenor, Isabela M.;Benzian, Habib;Bertozzi-Villa, Amelia;Beyene, Tariku Jibat;Bhala, Neeraj;Bhalla, Ashish;Bhutta, Zulfiqar A.;Bikbov, Boris;Bin Abdulhak, Aref;Biryukov, Stan;Blore, Jed D.;Blyth, Fiona M.;Bohensky, Megan A.;Borges, Guilherme;Bose, Dipan;Boufous, Soufiane;Bourne, Rupert R.;Boyers, Lindsay N.;Brainin, Michael;Brauer, Michael;Brayne, Carol E. G.;Brazinova, Alexandra;Breitborde, Nicholas;Brenner, Hermann;Briggs, Adam D. M.;Brown, Jonathan C.;Brugha, Traolach S.;Buckle, Geoffrey C.;Bui, Linh Ngoc;Bukhman, Gene;Burch, Michael;Nonato, Ismael Ricardo Campos;Carabin, Helesne;Cardenas, Rosario;Carapetis, Jonathan;Carpenter, David O.;Caso, Valeria;Castaneda-Orjuela, Carlos A.;Castro, Ruben Estanislao;Catala-Lopez, Ferrn;Cavalleri, Fiorella;Chang, Jung-Chen;Charlson, Fiona C.;Che, Xuan;Chen, Honglei;Chen, Yingyao;Chen, Jian Sheng;Chen, Zhengming;Chiang, Peggy Pei-Chia;Chimed-Ochir, Odgerel;Chowdhury, Rajiv;Christensen, Hanne;Christophi, Costas A.;Chuang, Ting-Wu;Chugh, Sumeet S.;Cirillo, Massimo;Coates, Matthew M.;Coffeng, Luc Edgar;Coggeshall, Megan S.;Cohen, Aaron;Colistro, Valentina;Colquhoun, Samantha M.;Colomar, Mercedes;Cooper, Leslie Trumbull;Cooper, Cyrus;Coppola, Luis M.;Cortinovis, Monica;Courville, Karen;Cowie, Benjamin C.;Criqui, Michael H.;Crump, John A.;Cuevas-Nasu, Lucia;Leite, Iuri da Costa;Dabhadkar, Kaustubh C.;Dandona, Lalit;Dandona, Rakhi;Dansereau, Emily;Dargan, Paul I.;Dayama, Anand;De la Cruz-Gongora, Vanessa;de la Vega, Shelley F.;De Leo, Diego;Degenhardt, Louisa;del Pozo-Cruz, Borja;Dellavalle, Robert P.;Deribe, Kebede;Jarlais, Don C. Des;Dessalegn, Muluken;deVeber, Gabrielle A.;Dharmaratne, Samath D.;Dherani, Mukesh;Diaz-Ortega, Jose-Luis;Diaz-Torne, Cesar;Dicker, Daniel;Ding, Eric L.;Dokova, Klara;Dorsey, E. Ray;Driscoll, Tim R.;Duan, Leilei;Duber, Herbert C.;Durrani, Adnan M.;Ebel, Beth E.;Edmond, Karen M.;Ellenbogen, Richard G.;Elshrek, Yousef;Ermakov, Sergey Petrovich;Erskine, Holly E.;Eshrati, Babak;Esteghamati, Alireza;Estep, Kara;Fuerst, Thomas;Fahimi, Saman;Fahrion, Anna S.;Faraon, Emerito Jose A.;Farzadfar, Farshad;Fay, Derek F. J.;Feigl, Andrea B.;Feigin, Valery L.;Felicio, Manuela Mendonca;Fereshtehnejad, Seyed-Mohammad;Fernandes, Jefferson G.;Ferrari, Alize J.;Fleming, Thomas D.;Foigt, Nataliya;Foreman, Kyle;Forouzanfar, Mohammad H.;Fowkes, F. Gerry R.;Fra Paleo, Urbano;Franklin, Richard C.;Futran, Neal D.;Gaffikin, Lynne;Gambashidze, Ketevan;Gankpe, Fortune Gbetoho;Garcia-Guerra, Francisco Armando;Garcia, Ana Cristina;Geleijnse, Johanna M.;Gessner, Bradford D.;Gibney, Katherine B.;Gillum, Richard F.;Gilmour, Stuart;Abdelmageem, Ibrahim;Ginawi, Mohamed;Giroud, Maurice;Glaser, Elizabeth L.;Goenka, Shifalika;Dantes, Hector Gomez;Gona, Philimon;Gonzalez-Medina, Diego;Guinovart, Caterina;Gupta, Rahul;Gupta, Rajeev;Gosselin, Richard A.;Gotay, Carolyn C.;Goto, Atsushi;Gowda, Hube N.;Graetz, Nicholas;Greenwell, K. Fern;Gugnani, Harish Chander;Gunnell, David;Gutierrez, Reyna A.;Haagsma, Juanita;Hafezi-Nejad, Nima;Hagan, Holly;Hagstromer, Maria;Halasa, Yara A.;Hamadeh, Randah Ribhi;Hamavid, Hannah;Hammami, Mouhanad;Hancock, Jamie;Hankey, Graeme J.;Hansen, Gillian M.;Harb, Hilda L.;Harewood, Heather;Haro, Josep Maria;Havmoeller, Rasmus;Hay, Roderick J.;Hay, Simon I.;Hedayati, Mohammad T.;Pi, Ileana B. Heredia;Heuton, Kyle R.;Heydarpour, Pouria;Higashi, Hideki;Hijar, Martha;Hoek, Hans W.;Hoffman, Howard J.;Hornberger, John C.;Hosgood, H. Dean;Hossain, Mazeda;Hotez, Peter J.;Hoy, Damian G.;Hsairi, Mohamed;Hu, Guoqing;Huang, John J.;Huffman, Mark D.;Hughes, Andrew J.;Husseini, Abdullatif;Huynh, Chantal;Iannarone, Marissa;Iburg, Kim M.;Idrisov, Bulat T.;Ikeda, Nayu;Innos, Kaire;Inoue, Manami;Islami, Farhad;Ismayilova, Samaya;Jacobsen, Kathryn H.;Jassal, Simerjot;Jayaraman, Sudha P.;Jensen, Paul N.;Jha, Vivekanand;Jiang, Guohong;Jiang, Ying;Jonas, Jost B.;Joseph, Jonathan;Juel, Knud;Kabagambe, Edmond Kato;Kan, Haidong;Karch, Andre;Karimkhani, Chante;Karthikeyan, Ganesan;Kassebaum, Nicholas;Kaul, Anil;Kawakami, Norito;Kazanjan, Konstantin;Kazi, Dhruv S.;Kemp, Andrew H.;Kengne, Andre Pascal;Keren, Andre;Kereselidze, Maia;Khader, Yousef Saleh;Khalifa, Shams Eldin Ali Hassan;Khan, Ejaz Ahmed;Khan, Gulfaraz;Khang, Young-Ho;Kieling, Christian;Kinfu, Yohannes;Kinge, Jonas M.;Kim, Daniel;Kim, Sungroul;Kivipelto, Miia;Knibbs, Luke;Knudsen, Ann Kristin;Kokubo, Yoshihiro;Kosen, Sowarta;Kotagal, Meera;Kravchenko, Michael A.;Krishnaswami, Sanjay;Krueger, Hans;Defo, Barthelemy Kuate;Kuipers, Ernst J.;Bicer, Burcu Kucuk;Kulkarni, Chanda;Kulkarni, Veena S.;Kumar, Kaushalendra;Kumar, Ravi B.;Kwan, Gene F.;Kyu, Hmwe;Lai, Taavi;Balaji, Arjun Lakshmana;Lalloo, Ratilal;Lallukka, Tea;Lam, Hilton;Lan, Qing;Lansingh, Van C.;Larson, Heidi J.;Larsson, Anders;Lavados, Pablo M.;Lawrynowicz, Alicia E. B.;Leasher, Janet L.;Lee, Jong-Tae;Leigh, James;Leinsalu, Mall;Leung, Ricky;Levitz, Carly;Li, Bin;Li, Yichong;Li, Yongmei;Liddell, Chelsea;Lim, Stephen S.;de Lima, Graca Maria Ferreira;Lind, Maggie L.;Lipshultz, Steven E.;Liu, Shiwei;Liu, Yang;Lloyd, Belinda K.;Lofgren, Katherine T.;Logroscino, Giancarlo;London, Stephanie J.;Lortet-Tieulent, Joannie;Lotufo, Paulo A.;Lucas, Robyn M.;Lunevicius, Raimundas;Lyons, Ronan Anthony;Ma, Stefan;Machado, Vasco Manuel Pedro;MacIntyre, Michael F.;Mackay, Mark T.;MacLachlan, Jennifer H.;Magis-Rodriguez, Carlos;Mahdi, Abbas A.;Majdan, Marek;Malekzadeh, Reza;Mangalam, Srikanth;Mapoma, Christopher Chabila;Marape, Marape;Marcenes, Wagner;Margono, Christopher;Marks, Guy B.;Marzan, Melvin Barrientos;Masci, Joseph R.;Mashal, Mohammad Taufi Q.;Masiye, Felix;Mason-Jones, Amanda J.;Matzopolous, Richard;Mayosi, Bongani M.;Mazorodze, Tasara T.;McGrath, John J.;Mckay, Abigail C.;Mckee, Martin;McLain, Abigail;Meaney, Peter A.;Mehndiratta, Man Mohan;Mejia-Rodriguez, Fabiola;Melaku, Yohannes Adama;Meltzer, Michele;Memish, Ziad A.;Mendoza, Walter;Mensah, George A.;Meretoja, Atte;Mhimbira, Francis A.;Miller, Ted R.;Mills, Edward J.;Misganaw, Awoke;Mishra, Santosh K.;Mock, Charles N.;Moffitt, Terrie E.;Ibrahim, Norlinah Mohamed;Mohammad, Karzan Abdulmuhsin;Mokdad, Ali H.;Mola, Glen Liddell;Monasta, Lorenzo;Monis, Jonathan de la Cruz;Hernandez, Julio C. Montaez;Montico, Marcella;Montine, Thomas J.;Mooney, Meghan D.;Moore, Ami R.;Moradi-Lakeh, Maziar;Moran, Andrew E.;Mori, Rintaro;Moschandreas, Joanna;Moturi, Wilkister Nyaora;Moyer, Madeline L.;Mozaffarian, Dariush;Mueller, Ulrich O.;Mukaigawara, Mitsuru;Mullany, Erin C.;Murray, Joseph;Mustapha, Adetoun;Naghavi, Paria;Naheed, Aliya;Naidoo, Kovin S.;Naldi, Luigi;Nand, Devina;Nangia, Vinay;Narayan, K. M. Venkat;Nash, Denis;Nasher, Jamal;Nejjari, Chakib;Nelson, Robert G.;Neuhouser, Marian;Neupane, Sudan Prasad;Newcomb, Polly A.;Newman, Lori;Newton, Charles R.;Ng, Marie;Ngalesoni, Frida Namnyak;Nguyen, Grant;Nhung Thi Trang Nguyen;Nisar, Muhammad Imran;Nolte, Sandra;Norheim, Ole F.;Norman, Rosana E.;Norrving, Bo;Nyakarahuka, Luke;Odell, Shaun;O'Donnell, Martin;Ohkubo, Takayoshi;Ohno, Summer Lockett;Olusanya, Bolajoko O.;Omer, Saad B.;Opio, John Nelson;Orisakwe, Orish Ebere;Ortblad, Katrina F.;Ortiz, Alberto;Otayza, Maria Lourdes K.;Pain, Amanda W.;Pandian, Jeyaraj D.;Panelo, Carlo Irwin;Panniyammakal, Jeemon;Papachristou, Christina;Paternina Caicedo, Angel J.;Patten, Scott B.;Patton, George C.;Paul, Vinod K.;Pavlin, Boris;Pearce, Neil;Pellegrini, Carlos A.;Pereira, David M.;Peresson, Sophie C.;Perez-Padilla, Rogelio;Perez-Ruiz, Fernando P.;Perico, Norberto;Pervaiz, Aslam;Pesudovs, Konrad;Peterson, Carrie B.;Petzold, Max;Phillips, Bryan K.;Phillips, David E.;Phillips, Michael R.;Plass, Dietrich;Piel, Frederic Bernard;Poenaru, Dan;Polinder, Suzanne;Popova, Svetlana;Poulton, Richie G.;Pourmalek, Farshad;Prabhakaran, Dorairaj;Qato, Dima;Quezada, Amado D.;Quistberg, D. Alex;Rabito, Felicia;Rafay, Anwar;Rahimi, Kazem;Rahimi-Movaghar, Vafa;Rahman, Sajjad U. R.;Raju, Murugesan;Rakovac, Ivo;Rana, Saleem M.;Refaat, Amany;Remuzzi, Giuseppe;Ribeiro, Antonio L.;Ricci, Stefano;Riccio, Patricia M.;Richardson, Lee;Richardus, Jan Hendrik;Roberts, Bayard;Roberts, D. Allen;Robinson, Margaret;Roca, Anna;Rodriguez, Alina;Rojas-Rueda, David;Ronfani, Luca;Room, Robin;Roth, Gregory A.;Rothenbacher, Dietrich;Rothstein, David H.;Rowley, Jane Tf;Roy, Nobhojit;Ruhago, George M.;Rushton, Lesley;Sambandam, Sankar;Soreide, Kjetil;Saeedi, Mohammad Yahya;Saha, Sukanta;Sahathevan, Ramesh;Sahraian, Mohammad Ali;Sahle, Berhe Weldearegawi;Salomon, Joshua A.;Salvo, Deborah;Samonte, Genesis May J.;Sampson, Uchechukwu;Sanabria, Juan Ramon;Sandar, Logan;Santos, Itamar S.;Satpathy, Maheswar;Sawhney, Monika;Saylan, Mete;Scarborough, Peter;Schoettker, Ben;Schmidt, Juergen C.;Schneider, Ione J. C.;Schumacher, Austin E.;Schwebel, David C.;Scott, James G.;Sepanlou, Sadaf G.;Servan-Mori, Edson E.;Shackelford, Katya;Shaheen, Amira;Shahraz, Saeid;Shakh-Nazarova, Marina;Shangguan, Siyi;She, Jun;Sheikhbahaei, Sara;Shepard, Donald S.;Shibuya, Kenji;Shinohara, Yukito;Shishani, Kawkab;Shiue, Ivy;Shivakoti, Rupak;Shrime, Mark G.;Sigfusdottir, Inga Dora;Silberberg, Donald H.;Silva, Andrea P.;Simard, Edgar P.;Sindi, Shireen;Singh, Jasvinder A.;Singh, Lavanya;Sioson, Edgar;Skirbekk, Vegard;Sliwa, Karen;So, Samuel;Soljak, Michael;Soneji, Samir;Soshnikov, Sergey S.;Sposato, Luciano A.;Sreeramareddy, Chandrashekhar T.;Stanaway, Jeff Rey D.;Stathopoulou, Vasiliki Kalliopi;Steenland, Kyle;Stein, Claudia;Steiner, Caitlyn;Stevens, Antony;Stoeckl, Heidi;Straif, Kurt;Stroumpoulis, Konstantinos;Sturua, Lela;Sunguya, Bruno F.;Swaminathan, Soumya;Swaroop, Mamta;Sykes, Bryan L.;Tabb, Karen M.;Takahashi, Ken;Talongwa, Roberto Tchio;Tan, Feng;Tanne, David;Tanner, Marcel;Tavakkoli, Mohammad;Ao, Braden Te;Teixeira, Carolina Maria;Templin, Tara;Tenkorang, Eric Yeboah;Terkawi, Abdullah Sulieman;Thomas, Bernadette A.;Thorne-Lyman, Andrew L.;Thrift, Amanda G.;Thurston, George D.;Tillmann, Taavi;Tirschwell, David L.;Tleyjeh, Imad M.;Tonelli, Marcello;Topouzis, Fotis;Towbin, Jeffrey A.;Toyoshima, Hideaki;Traebert, Jefferson;Tran, Bach X.;Truelsen, Thomas;Trujillo, Ulises;Trillini, Matias;Dimbuene, Zacharie Tsala;Tsilimbaris, Miltiadis;Tuzcu, E. Murat;Ubeda, Clotilde;Uchendu, Uche S.;Ukwaja, Kingsley N.;Undurraga, Eduardo A.;Vallely, Andrew J.;van de Vijver, Steven;van Gool, Coen H.;Varakin, Yuri Y.;Vasankari, Tommi J.;Vasconcelos, Ana Maria Nogales;Vavilala, Monica S.;Venketasubramanian, N.;Vijayakumar, Lakshmi;Villalpando, Salvador;Violante, Francesco S.;Vlassov, Vasiliy Victorovich;Wagner, Gregory R.;Waller, Stephen G.;Wang, JianLi;Wang, Linhong;Wang, XiaoRong;Wang, Yanping;Warouw, Tati Suryati;Weichenthal, Scott;Weiderpass, Elisabete;Weintraub, Robert G.;Wenzhi, Wang;Werdecker, Andrea;Wessells, K. Ryan R.;Westerman, Ronny;Whiteford, Harvey A.;Wilkinson, James D.;Williams, Thomas Neil;Woldeyohannes, Solomon Meseret;Wolfe, Charles D. A.;Wolock, Timothy M.;Woolf, Anthony D.;Wong, John Q.;Wright, Jonathan L.;Wulf, Sarah;Wurtz, Brittany;Xu, Gelin;Yang, Yang C.;Yano, Yuichiro;Yatsuya, Hiroshi;Yip, Paul;Yonemoto, Naohiro;Yoon, Seok-Jun;Younis, Mustafa;Yu, Chuanhua;Jin, Kim Yun;Zaki, Maysaa El Sayed;Zamakhshary, Mohammed Fouad;Zeeb, Hajo;Zhang, Yong;Zhao, Yong;Zheng, Yingfeng;Zhu, Jun;Zhu, Shankuan;Zonies, David;Zou, Xiao Nong;Zunt, Joseph R.;Vos, Theo;Lopez, Alan D.;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
1.9
作者：
Hassan, Eman M.;Omran, Dalia A.;El Askary, Ahmad
通讯作者：
El Askary, Ahmad
影响因子：
9.8
作者：
Giannini, Edoardo G.;Zaman, Atif;Testa, Roberto
通讯作者：
Testa, Roberto
影响因子：
4.3
作者：
Xu, Xiao-Dan;Dai, Jian-Jun;Wang, Wei-Jun
通讯作者：
Wang, Wei-Jun
影响因子：
4.3
作者：
Gonzalez-Ojeda, Alejandro;Cervantes-Guevara, Gabino;Fuentes-Orozco, Clotilde
通讯作者：
Fuentes-Orozco, Clotilde