Prenatal Adversity Alters the Epigenetic Profile of the Prefrontal Cortex: Sexually Dimorphic Effects of Prenatal Alcohol Exposure and Food-Related Stress.
Prenatal Adversity Alters the Epigenetic Profile of the Prefrontal Cortex: Sexually Dimorphic Effects of Prenatal Alcohol Exposure and Food-Related Stress.
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DOI：
10.3390/genes12111773
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发表时间：
2021-11-09
期刊：
影响因子：
3.5
通讯作者：
Weinberg J
中科院分区：
文献类型：
--
作者：
Lussier AA;Bodnar TS;Moksa M;Hirst M;Kobor MS;Weinberg J
产前逆境或压力可能对发育轨迹和健康结果产生长期影响。虽然这些影响背后的生物学机制知之甚少，但表观遗传修饰，如DNA甲基化，有可能将早期生活环境与生理系统的改变联系起来，并具有长期的功能影响。我们研究了两种产前侮辱，产前酒精暴露（PAE）和食物相关的压力，对大鼠大脑发育早期的DNA甲基化谱的后果。由于这些侮辱可能对生物学结果产生性别特异性影响，我们分析了男性和女性前额叶皮层的表观基因组DNA甲基化模式，这是一个涉及认知，执行功能和行为的关键大脑区域。我们发现这些侮辱的表观遗传模式的性别依赖性和性别一致性的影响。这些改变发生在与大脑发育和免疫功能相关的基因和途径中，表明PAE和食物相关的应激可能部分通过中枢表观遗传变化重新编程神经生物学/生理系统，并且可能以性别依赖的方式进行。这种表观遗传学变化可能反映了产前损伤对长期功能和健康结果的性别特异性影响，并对了解胎儿酒精谱系障碍和其他神经发育障碍的可能机制具有重要意义。
Prenatal adversity or stress can have long-term consequences on developmental trajectories and health outcomes. Although the biological mechanisms underlying these effects are poorly understood, epigenetic modifications, such as DNA methylation, have the potential to link early-life environments to alterations in physiological systems, with long-term functional implications. We investigated the consequences of two prenatal insults, prenatal alcohol exposure (PAE) and food-related stress, on DNA methylation profiles of the rat brain during early development. As these insults can have sex-specific effects on biological outcomes, we analyzed epigenome-wide DNA methylation patterns in prefrontal cortex, a key brain region involved in cognition, executive function, and behavior, of both males and females. We found sex-dependent and sex-concordant influences of these insults on epigenetic patterns. These alterations occurred in genes and pathways related to brain development and immune function, suggesting that PAE and food-related stress may reprogram neurobiological/physiological systems partly through central epigenetic changes, and may do so in a sex-dependent manner. Such epigenetic changes may reflect the sex-specific effects of prenatal insults on long-term functional and health outcomes and have important implications for understanding possible mechanisms underlying fetal alcohol spectrum disorder and other neurodevelopmental disorders.
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影响因子：
14.9
作者：
Gatev E;Inkster AM;Negri GL;Konwar C;Lussier AA;Skakkebaek A;Sokolowski MB;Gravholt CH;Dunn EC;Kobor MS;Aristizabal MJ
通讯作者：
Aristizabal MJ
血液DNA甲基化和自闭症谱系障碍的病例对照荟萃分析。
影响因子：
6.2
作者：
Andrews SV;Sheppard B;Windham GC;Schieve LA;Schendel DE;Croen LA;Chopra P;Alisch RS;Newschaffer CJ;Warren ST;Feinberg AP;Fallin MD;Ladd-Acosta C
通讯作者：
Ladd-Acosta C
DOI：
10.1073/pnas.1820838116
发表时间：
2020-09-22
影响因子：
11.1
作者：
Aristizabal, Maria J.;Anreiter, Ina;O'Donnell, Kieran J.
通讯作者：
O'Donnell, Kieran J.
影响因子：
14.5
作者：
de Rooij, Susanne R.;Caan, Matthan W. A.;Roseboom, Tessa J.
通讯作者：
Roseboom, Tessa J.
影响因子：
3.8
作者：
Fransquet PD;Hutchinson D;Olsson CA;Wilson J;Allsop S;Najman J;Elliott E;Mattick RP;Saffery R;Ryan J;Triple B Research Consortium
通讯作者：
Triple B Research Consortium