Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance.
Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance.
复制标题
DOI：
10.3389/fmicb.2013.00353
复制
发表时间：
2013-12-09
影响因子：
5.2
通讯作者：
Kyaw CM
中科院分区：
文献类型：
--
作者：
Guilhelmelli F;Vilela N;Albuquerque P;Derengowski Lda S;Silva-Pereira I;Kyaw CM
抗菌肽(AMPs)是由哺乳动物、节肢动物、植物和细菌等各种生物产生的天然抗生素。除了抗菌活性外，AMPs还可以诱导趋化因子的产生，促进血管生成，促进伤口愈合，调节多细胞生物体的细胞凋亡。最初，它们的抗菌作用机制被认为仅仅是增加病原体细胞膜的通透性，但已经证明几种AMP在最低致死浓度下并不调节细胞膜的通透性。相反，它们通过抑制蛋白质和细胞壁合成以及酶活性等过程发挥作用。虽然对这些分子的耐药性并不常见，但一些病原菌发展了不同的策略来克服AMPs的杀伤，如表面修饰、外排泵的表达和蛋白水解酶的分泌等。本文综述了AMPs的各种作用机制以及病原菌如何对其产生抗性。
Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can induce chemokine production, accelerate angiogenesis, and wound healing and modulate apoptosis in multicellular organisms. Originally, their antimicrobial mechanism of action was thought to consist solely of an increase in pathogen cell membrane permeability, but it has already been shown that several AMPs do not modulate membrane permeability in the minimal lethal concentration. Instead, they exert their effects by inhibiting processes such as protein and cell wall synthesis, as well as enzyme activity, among others. Although resistance to these molecules is uncommon several pathogens developed different strategies to overcome AMPs killing such as surface modification, expression of efflux pumps, and secretion of proteases among others. This review describes the various mechanisms of action of AMPs and how pathogens evolve resistance to them.
登录
查看更多内容
影响因子：
6.7
作者：
Cullen TW;Giles DK;Wolf LN;Ecobichon C;Boneca IG;Trent MS
通讯作者：
Trent MS
影响因子：
3.3
作者：
CHATTERJEE, S;CHATTERJEE, DK;SEIBERT, G
通讯作者：
SEIBERT, G
影响因子：
4.8
作者：
Chan, C;Burrows, LL;Deber, CM
通讯作者：
Deber, CM
影响因子：
4.9
作者：
Bachrach, Gilad;Altman, Hamutal;Steinberg, Doron
通讯作者：
Steinberg, Doron
影响因子：
4.8
作者：
Andrae, Joerg;Goldmann, Torsten;Gutsmann, Thomas
通讯作者：
Gutsmann, Thomas