NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain.
NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain.
复制标题
NMDAR 介导外周和中枢敏化，导致慢性口面部疼痛
DOI：
10.3389/fncel.2022.999509
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发表时间：
2022
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
三叉神经系统的周围和中枢敏化是促进三叉神经损伤或炎症后慢性口面部疼痛发生和维持的主要机制，慢性口面部疼痛的特征是异常性疼痛、痛觉过敏和异位痛。尽管慢性口面部疼痛的病理机制复杂且尚不为人所知，但足够的临床和临床前证据支持N-甲基-D-天冬氨酸受体（NMDAR，离子型谷氨酸受体的一个亚类）在各种病理条件下对三叉神经伤害性信号处理通路的贡献。 NMDAR 不仅被认为是周围神经系统 (PNS) 中疼痛相关神经可塑性的潜在介质，而且还介导中枢神经系统 (CNS) 中的兴奋性突触传递和突触可塑性。在这篇综述中，我们重点关注 NMDAR 在口面部神经病理性疼痛和炎性疼痛下三叉神经系统中的关键作用和机制。我们特别总结了三叉神经系统中 NMDAR 的类型、成分和分布。此外，我们还讨论了 NMDAR 介导的神经元-非神经元细胞/神经元-神经元通讯在神经性损伤和炎症后慢性口面部疼痛的外周机制中的调节作用。此外，我们回顾了 NMDAR 在口面部神经性疼痛和炎性疼痛条件下的上升和下降回路中的功能作用和机制，这有助于中枢敏化。这些发现不仅与理解潜在机制相关，而且为慢性口面部疼痛的靶向治疗提供了新的思路。
Peripheral and central sensitizations of the trigeminal nervous system are the main mechanisms to promote the development and maintenance of chronic orofacial pain characterized by allodynia, hyperalgesia, and ectopic pain after trigeminal nerve injury or inflammation. Although the pathomechanisms of chronic orofacial pain are complex and not well known, sufficient clinical and preclinical evidence supports the contribution of the N-methyl-D-aspartate receptors (NMDARs, a subclass of ionotropic glutamate receptors) to the trigeminal nociceptive signal processing pathway under various pathological conditions. NMDARs not only have been implicated as a potential mediator of pain-related neuroplasticity in the peripheral nervous system (PNS) but also mediate excitatory synaptic transmission and synaptic plasticity in the central nervous system (CNS). In this review, we focus on the pivotal roles and mechanisms of NMDARs in the trigeminal nervous system under orofacial neuropathic and inflammatory pain. In particular, we summarize the types, components, and distribution of NMDARs in the trigeminal nervous system. Besides, we discuss the regulatory roles of neuron-nonneuronal cell/neuron-neuron communication mediated by NMDARs in the peripheral mechanisms of chronic orofacial pain following neuropathic injury and inflammation. Furthermore, we review the functional roles and mechanisms of NMDARs in the ascending and descending circuits under orofacial neuropathic and inflammatory pain conditions, which contribute to the central sensitization. These findings are not only relevant to understanding the underlying mechanisms, but also shed new light on the targeted therapy of chronic orofacial pain.
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DOI：
10.1111/j.1460-9568.2012.08100.x
发表时间：
2012-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Okamoto K;Tashiro A;Chang Z;Thompson R;Bereiter DA
通讯作者：
Bereiter DA
影响因子：
2.5
作者：
BOWER, JM;WOOLSTON, DC
通讯作者：
WOOLSTON, DC
影响因子：
1.9
作者：
Cavalcante, Andre L. C.;Siqueira, Rafaelly M. P.;Vale, Mariana L.
通讯作者：
Vale, Mariana L.
影响因子：
8.8
作者：
Chen J;Li L;Chen SR;Chen H;Xie JD;Sirrieh RE;MacLean DM;Zhang Y;Zhou MH;Jayaraman V;Pan HL
通讯作者：
Pan HL
影响因子：
4.9
作者：
Benoliel, Rafael;May, Arne;Ohrbach, Richard
通讯作者：
Ohrbach, Richard