Temporomandibular joint-evoked responses by spinomedullary neurons and masseter muscle are enhanced after repeated psychophysical stress.
Temporomandibular joint-evoked responses by spinomedullary neurons and masseter muscle are enhanced after repeated psychophysical stress.
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DOI：
10.1111/j.1460-9568.2012.08100.x
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Bereiter DA
中科院分区：
文献类型：
--
作者：
Okamoto K;Tashiro A;Chang Z;Thompson R;Bereiter DA
心理压力是导致头部和颈部肌肉骨骼疼痛的危险因素；然而，这种关系的基础仍然不确定。这项研究验证了心理物理应激足以改变雄性大鼠脊髓延髓背角神经元的编码特性和咬肌活动的假设。反复强迫游泳可显著增加背角深部神经元的背景放电频率和TMJ诱发活动，而对浅板层神经元的影响较小。应激还使深、浅背角神经元对位于TMJ上的面部皮肤刺激的反应增强。TMJ诱发的咬肌活动在应激大鼠显著增强，这种作用被预先阻断脊髓延髓交界区而减弱。这些数据表明，反复的心理物理应激对延髓背角神经元的特性和咬肌活动产生广泛的影响。应激主要影响深背角的神经元，包括对来自TMJ的化学感觉输入和来自上覆面部皮肤的机械输入的增强反应。应激诱导的TMJ诱发的咬肌活动的增加与背角神经元的变化很好地匹配。结论：脊髓延髓交界区在心理物理应激和与伤害性信息有关的感觉信息的整合中起着关键作用。
Psychological stress is a risk factor to develop musculoskeletal pain of the head and neck; however, the basis for this relationship remains uncertain. This study tested the hypothesis that psychophysical stress alone was sufficient to alter the encoding properties of spinomedullary dorsal horn neurons and masseter muscle activity in male rats. Repeated forced swim conditioning increased markedly both the background firing rate and temporomandibular joint (TMJ)-evoked activity of neurons in deep dorsal horn, while neurons in superficial laminae were less affected. Stress also increased the responses to stimulation of facial skin overlying the TMJ of neurons in deep and superficial dorsal horn. TMJ-evoked masseter muscle activity was enhanced significantly in stressed rats, an effect that was reduced by prior blockade of the spinomedullary junction region. These data indicated that repeated psychophysical stress induced widespread effects on the properties of medullary dorsal horn neurons and masseter muscle activity. The effects of stress were seen preferentially on neurons in deep dorsal horn and included enhanced responses to chemosensory input from the TMJ and mechanical input from overlying facial skin. The stress-induced elevation in TMJ-evoked masseter muscle activity matched well the changes seen in dorsal horn neurons. It is concluded that the spinomedullary junction region plays a critical role in the integration of psychophysical stress and sensory information relevant for nociception involving deep craniofacial tissues.
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