Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
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二芳基三氮烯作为抗菌剂，对抗耐甲氧西林金黄色葡萄球菌 (MRSA) 和耻垢分枝杆菌。
DOI：
10.1016/j.ejmech.2016.12.060
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发表时间：
2017
影响因子：
6.7
通讯作者：
Vajs J
中科院分区：
文献类型：
--
作者：
Vajs J
合成了二芳基三氮烯衍生物并评估了其抗菌特性。初步实验表明，其中一些化合物对耐甲氧西林金黄色葡萄球菌 (MRSA) 和耻垢分枝杆菌均具有活性，MIC 分别为 0.02 和 0.03 μg/mL。未发现那些具有有效抗葡萄球菌和抗分枝杆菌活性的化合物可作为哺乳动物细胞系或酵母的生长抑制剂。此外，我们证明最活跃的抗 MRSA 二芳基三氮烯衍生物之一的耐药频率非常低，<10−9。抗性分离株的全基因组测序发现了裂解磷脂的酶的突变。这可能导致磷脂代谢的改变，从而改变葡萄球菌细胞膜的特征，最终改变这些病原体对三氮烯攻击的敏感性。因此，我们的工作扩展了三氮烯的潜在范围，这可能会产生低耐药性的新型抗菌药物。
Diaryltriazene derivatives were synthesized and evaluated for their antimicrobial properties. Initial experiments showed some of these compounds to have activity against both methicillin-resistant strains ofStaphylococus aureus(MRSA) and Mycobacterium smegmatis, with MICs of 0.02 and 0.03 μg/mL respectively. Those compounds with potent anti-staphylococcal and anti-mycobacterial activity were not found to act as growth inhibitors of mammalian cell lines or yeast. Furthermore, we demonstrated that one of the most active anti-MRSA diaryltriazene derivatives was subject to very low frequencies of resistance at <10−9. Whole genome sequencing of resistant isolates identified mutations in the enzyme that lysylates phospholipids. This could result in the modification of phospholipid metabolism and consequently the characteristics of the staphylococcal cell membrane, ultimately modifying the sensitivity of these pathogens to triazene challenge. Our work has therefore extended the potential range of triazenes, which could yield novel antimicrobials with low levels of resistance.
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影响因子：
--
作者：
MICKISCH, G;FAJTA, S;ALKEN, P
通讯作者：
ALKEN, P
影响因子：
15
作者：
Tiwari, Rohit;Moraski, Garrett C.;Krchnak, Viktor;Miller, Patricia A.;Colon-Martinez, Mariangelli;Herrero, Eliza;Oliver, Allen G.;Miller, Marvin J.
通讯作者：
Miller, Marvin J.
新型羟基三氮烯的抗菌和抗真菌活性
DOI：
--
发表时间：
2012
期刊：
影响因子：
--
作者：
A. O. Ombaka;Muguna;Gichumbi
通讯作者：
Gichumbi
影响因子：
64.8
作者：
Ling LL;Schneider T;Peoples AJ;Spoering AL;Engels I;Conlon BP;Mueller A;Schäberle TF;Hughes DE;Epstein S;Jones M;Lazarides L;Steadman VA;Cohen DR;Felix CR;Fetterman KA;Millett WP;Nitti AG;Zullo AM;Chen C;Lewis K
通讯作者：
Lewis K
用六硝基钴(III)钠进行亚硝化。
影响因子：
3.6
作者：
B. Štefane;M. Kočevar;S. Polanc
通讯作者：
S. Polanc