Extended Amygdala Neuropeptide Circuitry of Emotional Arousal: Waking Up on the Wrong Side of the Bed Nuclei of Stria Terminalis.
Extended Amygdala Neuropeptide Circuitry of Emotional Arousal: Waking Up on the Wrong Side of the Bed Nuclei of Stria Terminalis.
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DOI：
10.3389/fnbeh.2021.613025
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发表时间：
2021
影响因子：
3
通讯作者：
Pomrenze MB
中科院分区：
文献类型：
--
作者：
Giardino WJ;Pomrenze MB
睡眠是生活的基础，睡眠质量差与处理和响应情绪刺激的神经回路的次优功能有关。觉醒（“觉醒”）主要由昼夜节律和自我平衡的力量调节，但情感情绪状态也强烈影响睡眠和觉醒之间的平衡。考虑到睡眠/觉醒变化和情绪动力学之间的双向关系，我们使用术语“情绪觉醒”作为大脑通路之间深刻重叠的代表性特征：（1）调节觉醒;（2）解释情绪信息;（3）校准动机行为。有趣的是，许多情绪唤醒回路使用称为神经肽的专门信号分子进行通信，以广泛地修改神经网络活动。一个主要的富含神经肽的大脑区域是终纹床核（BNST），它对情绪处理至关重要，最近被认为与睡眠调节有关，它是杏仁核（一个解剖学术语，也包括中央杏仁核和内侧杏仁核、杏仁核壳和两者之间的过渡区）的核心组成部分。BNST包括惊人的细胞类型多样性，这些细胞类型在许多特征上不同，包括空间组织、分子特征、生物性别和激素环境、突触输入、轴突输出、神经生理学通信模式和功能作用。鉴于这种巨大的复杂性，全面阐明BNST神经肽回路机制的情绪唤醒提出了一系列雄心勃勃的挑战。在这篇综述中，我们描述了如何对这些未解决的问题进行严格的调查，以揭示加强精神病治疗和全球心理健康的关键见解。
Sleep is fundamental to life, and poor sleep quality is linked to the suboptimal function of the neural circuits that process and respond to emotional stimuli. Wakefulness (“arousal”) is chiefly regulated by circadian and homeostatic forces, but affective mood states also strongly impact the balance between sleep and wake. Considering the bidirectional relationships between sleep/wake changes and emotional dynamics, we use the term “emotional arousal” as a representative characteristic of the profound overlap between brain pathways that: (1) modulate wakefulness; (2) interpret emotional information; and (3) calibrate motivated behaviors. Interestingly, many emotional arousal circuits communicate using specialized signaling molecules called neuropeptides to broadly modify neural network activities. One major neuropeptide-enriched brain region that is critical for emotional processing and has been recently implicated in sleep regulation is the bed nuclei of stria terminalis (BNST), a core component of the extended amygdala (an anatomical term that also includes the central and medial amygdalae, nucleus accumbens shell, and transition zones betwixt). The BNST encompasses an astonishing diversity of cell types that differ across many features including spatial organization, molecular signature, biological sex and hormonal milieu, synaptic input, axonal output, neurophysiological communication mode, and functional role. Given this tremendous complexity, comprehensive elucidation of the BNST neuropeptide circuit mechanisms underlying emotional arousal presents an ambitious set of challenges. In this review, we describe how rigorous investigation of these unresolved questions may reveal key insights to enhancing psychiatric treatments and global psychological wellbeing.
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影响因子：
5.7
作者：
Avery SN;Clauss JA;Winder DG;Woodward N;Heckers S;Blackford JU
通讯作者：
Blackford JU
DOI：
10.1523/jneurosci.2827-10.2010
发表时间：
2010-12-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Briand LA;Vassoler FM;Pierce RC;Valentino RJ;Blendy JA
通讯作者：
Blendy JA
影响因子：
5.3
作者：
Bangasser, Debbie A.;Shors, Tracey J.
通讯作者：
Shors, Tracey J.
影响因子：
2
作者：
Bjorni, Max;Rovero, Natalie G.;Halladay, Lindsay R.
通讯作者：
Halladay, Lindsay R.
DOI：
10.1016/b978-0-12-815134-1.00003-9
发表时间：
2020-01-01
期刊：
Handbook of behavioral neuroscience
影响因子：
--
作者：
Beyeler, Anna;Dabrowska, Joanna
通讯作者：
Dabrowska, Joanna