BNST neurocircuitry in humans.
BNST neurocircuitry in humans.
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DOI：
10.1016/j.neuroimage.2014.01.017
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发表时间：
2014-05-01
期刊：
影响因子：
5.7
通讯作者：
Blackford JU
中科院分区：
文献类型：
--
作者：
Avery SN;Clauss JA;Winder DG;Woodward N;Heckers S;Blackford JU
焦虑和成瘾障碍是美国最常见的两种精神障碍，通常是慢性的、致残的和共病的。新出现的证据表明，终纹床核（BNST）通过与其他大脑区域（包括杏仁核和杏仁核）的连接来介导焦虑和成瘾。虽然BNST结构连接已被确定在啮齿动物和有限数量的结构连接已被证实在非人类灵长类动物，BNST连接尚未被描述在人类。神经影像学是一种强有力的工具，用于识别体内的结构和功能电路。在这项研究中，我们研究了BNST的结构和功能连接在一个大样本的人类。BNST与多个皮质下区域（包括边缘系统、丘脑和基底神经节结构）具有结构和功能联系，证实了啮齿动物的结构发现。我们描述了两个新的连接在人类大脑中，以前没有在啮齿类动物或非人类灵长类动物，包括颞极的结构连接，与扣带回旁回的功能连接。这项研究的结果提供了一个健康人大脑中BNST结构和功能连接的地图。在很大程度上，人类的BNST神经回路与啮齿动物和非人类灵长类动物的发现相似;然而，有几种连接是人类独有的。未来对焦虑和成瘾障碍中BNST神经回路的探索有可能揭示这些致残精神疾病的新机制。
Anxiety and addiction disorders are two of the most common mental disorders in the United States, and are typically chronic, disabling, and comorbid. Emerging evidence suggests the bed nucleus of the stria terminalis (BNST) mediates both anxiety and addiction through connections with other brain regions, including the amygdala and nucleus accumbens. Although BNST structural connections have been identified in rodents and a limited number of structural connections have been verified in non-human primates, BNST connections have yet to be described in humans. Neuroimaging is a powerful tool for identifying structural and functional circuits in vivo. In this study, we examined BNST structural and functional connectivity in a large sample of humans. The BNST has structural and functional connections with multiple subcortical regions, including limbic, thalamic, and basal ganglia structures, confirming structural findings in rodents. We describe two novel connections in the human brain that have not been previously reported in rodents or non-human primates, including structural connections with the temporal pole, and functional connections with the paracingulate gyrus. The findings of this study provide a map of the BNST’s structural and functional connectivity across brain in healthy humans. In large part, the BNST neurocircuitry in humans is similar to findings from rodents and non-human primates; however, several connections are unique to humans. Future explorations of BNST neurocircuitry in anxiety and addiction disorders have the potential to reveal novel mechanisms underlying these disabling psychiatric illnesses.
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DOI：
10.1098/rstb.1997.0149
发表时间：
1997-11-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Davis, M;Walker, DL;Lee, Y
通讯作者：
Lee, Y
影响因子：
2.5
作者：
Dong, HW;Swanson, LW
通讯作者：
Swanson, LW
影响因子：
7.9
作者：
Bangasser DA
通讯作者：
Bangasser DA
影响因子：
5.7
作者：
Alvarez RP;Chen G;Bodurka J;Kaplan R;Grillon C
通讯作者：
Grillon C
影响因子：
5.7
作者：
Chai, Xiaoqian J.;Castanon, Alfonso Nieto;Oenguer, Dost;Whitfield-Gabrieli, Susan
通讯作者：
Whitfield-Gabrieli, Susan