Hepatitis C virus and the controversial role of the interferon sensitivity determining region in the response to interferon treatment
Hepatitis C virus and the controversial role of the interferon sensitivity determining region in the response to interferon treatment
复制标题
丙型肝炎病毒和干扰素敏感性决定区在干扰素治疗反应中的争议性作用
DOI：
--
复制
发表时间：
2008
影响因子：
12.7
通讯作者：
F. González
中科院分区：
文献类型：
--
作者：
M. Torres;J. Cuevas;Nuria Jimenéz;M. Bracho;I. García;F. Carnicer;J. D. Del Olmo;E. Ortega;A. Moya;F. González
丙型肝炎病毒（HCV）基因组中干扰素敏感性决定区（ISDR）的变异性程度已被假定为预测对干扰素治疗的反应，主要是在1b亚型感染的患者中，尽管这一预测一直是长期争议的主题。通过分析67名西班牙HCV基因型1感染患者的队列，对这一预测进行了验证，其中23名感染了1a亚型，44名感染了1b亚型。获得了先前用α‐干扰素加利巴韦林治疗的样本，并对每个患者包括ISDR在内的几个克隆（25 - 96个）进行了测序。已检测到1b亚型患者的ISDR突变与治疗反应之间存在显著相关性，但与1a亚型感染患者无关。尽管结果表明，同样的关系也适用于1a亚型，但由于该亚型的样本量小，缺乏统计能力，因此无法得出更确切的结论。然而，在有应答和无应答的患者中发现了相同的ISDR序列，这表明ISDR序列的稳定性偶尔可以帮助HCV逃避干扰素治疗，尽管这不是充分条件。可能存在更复杂的相互作用，包括是否存在ISDR，并控制着HCV对干扰素治疗的反应。中华医学杂志，32(2):357 - 357,2008。©2007 Wiley‐Liss, Inc。
The degree of variability of the interferon sensitivity determining region (ISDR) in the hepatitis C virus (HCV) genome has been postulated to predict the response to interferon therapy, mainly in patients infected with subtype 1b, although this prediction has been the subject of a long controversy. This prediction has been tested by analyzing a cohort of 67 Spanish patients infected with HCV genotype 1, 23 of which were infected with subtype 1a and 44 with subtype 1b. A sample previous to therapy with α‐interferon plus ribavirin was obtained and several clones (between 25 and 96) including the ISDR were sequenced from each patient. A significant correlation between mutations at the ISDR and response to treatment for subtype 1b patients, but not for those infected with subtype 1a, has been detected. Although the results suggest that the same relationship holds true for subtype 1a, lack of statistical power because of the small sample size of this subtype prevented firmer conclusions. However, identical ISDR sequences were found in responder and non‐responder patients, suggesting that the stability of the ISDR sequence can occasionally help HCV to evade interferon therapy, although this is not a sufficient condition. More complex interactions, including the ISDR or not, are likely to exist and govern the HCV response to interferon treatment. J. Med. Virol. 80:247–253, 2008. © 2007 Wiley‐Liss, Inc.
登录
查看更多内容
DOI：
10.1016/s0928-0197(98)00034-8
发表时间：
1998-07
期刊：
Clinical and diagnostic virology
影响因子：
--
作者：
M. Gale;M. J. Korth;M. Katze
通讯作者：
M. Gale;M. J. Korth;M. Katze
非裔美国人和白人患者中丙型肝炎病毒基因型 1a NS5A 预处理序列变异和病毒动力学。
DOI：
10.1086/432760
发表时间：
2005
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Layden-Almer,JenniferE;Kuiken,Carla;Ribeiro,RuyM;Kunstman,KevinJ;Perelson,AlanS;Layden,ThomasJ;Wolinsky,StevenM
通讯作者：
Wolinsky,StevenM
影响因子：
56.9
作者：
Taylor, DR;Shi, ST;Lai, MMC
通讯作者：
Lai, MMC
影响因子：
3.7
作者：
Gale, MJ;Korth, MJ;Katze, MG
通讯作者：
Katze, MG
影响因子：
56.9
作者：
Blight, KJ;Kolykhalov, AA;Rice, CM
通讯作者：
Rice, CM