The relationship between ambulatory arterial stiffness index and left ventricular diastolic dysfunction in HFpEF: a prospective observational study.
The relationship between ambulatory arterial stiffness index and left ventricular diastolic dysfunction in HFpEF: a prospective observational study.
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DOI：
10.1186/s12872-022-02679-6
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发表时间：
2022-06-02
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
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射血分数(HFpEF)正常的心力衰竭患者的动态动脉僵硬指数(AASI)与左室舒张功能不全(LVDD)之间的关系尚不清楚。我们的目的是研究AASI与HFpEF的LVDD之间的关系。我们在重庆前瞻性地招募了连续的高血压性肺功能衰竭患者，中国。每例患者均进行24小时动态血压监测(24小时动态血压监测)和超声心动图检查。AASI是通过个人24h-ABPM获得的。分析AASI与LVDD的关系。共纳入107例HFpEF患者。平均年龄68.45 ± 14.02岁，女性63例(59%)。根据AASI上界(0.55)将患者分为两组。AASI >； 0.55组较AASI组 ≤ 0.55组年龄更大，平均收缩压更高，左室舒张功能更差。AASI与平均E/e‘(r = 0.307，P = 0.001)、间隔E/e’(r = 0.290，P = 0.002)、侧壁E/e‘(r = 0.276，P = 0.004)、E(r = 0.274，P = 0.004)呈正相关。调整传统危险因素后，AASI仍是高血压性心衰患者平均E/e‘ >； 10的独立危险因素(OR：2.929，95%CI：1.214~7.064，P = 0.017)，AASI与平均E/e’ &Gt； 14的相关性降低(OR：2.457，95%CI：1.030~5.860，P = 0.043)。AASI对平均E/e‘ &> 10有部分预测价值(AUC = 0.691，P = 0.002)，而对平均E/e’ &> 14的预测价值减弱(AUC = 0.624，P = 0.034)。AASI与HFpEF的E/e‘呈正相关，可能是平均E/e’升高的独立危险因素。网上版载有补充材料，可在10.1186/s12872-022-02679-6查阅。
The relationship between ambulatory arterial stiffness index (AASI) and left ventricular diastolic dysfunction (LVDD) in patients with heart failure with preserved ejection fraction (HFpEF) is unknown. We aimed to investigate the association between the AASI and LVDD in HFpEF. We prospective enrolled consecutive patients with HFpEF in Chongqing, China. Twenty-four-hour ambulatory blood pressure monitoring (24 h-ABPM) and echocardiography were performed in each patient. AASI was obtained through individual 24 h-ABPM. The relationship between AASI and LVDD was analyzed. A total of 107 patients with HFpEF were included. The mean age was 68.45 ± 14.02 years and 63 (59%) were women. The patients were divided into two groups according to the upper normal border of AASI (0.55). AASI > 0.55 group were more likely to be older, to have higher mean systolic blood pressure and worsen left ventricular diastolic function than AASI group ≤ 0.55. AASI was closely positive related to the diastolic function parameters, including mean E/e′ (r = 0.307, P = 0.001), septal E/e′ (r = 0.290, P = 0.002), lateral E/e′ (r = 0.276, P = 0.004) and E (r = 0.274, P = 0.004). After adjusting for conventional risk factors, AASI was still an independent risk factors of mean E/e′ > 10 in patients with HFpEF (OR: 2.929, 95%CI: 1.214–7.064, P = 0.017), and the association between AASI and mean E/e′ > 14 was reduced (OR: 2.457, 95%CI: 1.030–5.860, P = 0.043). AASI had a partial predictive value for mean E/e′ > 10 (AUC = 0.691, P = 0.002), while the predictive value for mean E/e′ > 14 was attenuated (AUC = 0.624, P = 0.034). AASI was positive related to E/e′ in HFpEF and might be an independent risk factor for the increase of mean E/e′. The online version contains supplementary material available at 10.1186/s12872-022-02679-6.
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影响因子：
37.8
作者：
Shah SJ;Kitzman DW;Borlaug BA;van Heerebeek L;Zile MR;Kass DA;Paulus WJ
通讯作者：
Paulus WJ
影响因子：
1.5
作者：
Sharma AK;Kumar H;Razi MM;Sinha SK;Pandey U;Shukla P;Thakur R;Verma CM;Bansal RK;Krishna V
通讯作者：
Krishna V
影响因子：
8.3
作者：
Adiyaman, Ahmet;Dechering, Dirk G.;Staessen, Jan A.
通讯作者：
Staessen, Jan A.
锻炼心力衰竭的耐耐受性，并保留了射血分数：运动过程中动脉刚度和敏感性左心室血液动力学反应。
影响因子：
6
作者：
Zern EK;Ho JE;Panah LG;Lau ES;Liu E;Farrell R;Sbarbaro JA;Schoenike MW;Pappagianopoulos PP;Namasivayam M;Malhotra R;Nayor M;Lewis GD
通讯作者：
Lewis GD
影响因子：
1.3
作者：
Li, Y;Dolan, E;Stanton, A
通讯作者：
Stanton, A