To determine the correlation between echocardiographic diastolic parameters and invasively measured left ventricular end diastolic pressure in patients with heart failure with preserved ejection fraction- an observational, descriptive study. (CEAL-HFpEF study).
To determine the correlation between echocardiographic diastolic parameters and invasively measured left ventricular end diastolic pressure in patients with heart failure with preserved ejection fraction- an observational, descriptive study. (CEAL-HFpEF study).
复制标题
DOI：
10.1016/j.ihj.2021.06.012
复制
发表时间：
2021-07
影响因子：
1.5
通讯作者：
Krishna V
中科院分区：
文献类型：
--
作者：
Sharma AK;Kumar H;Razi MM;Sinha SK;Pandey U;Shukla P;Thakur R;Verma CM;Bansal RK;Krishna V
虽然有创监测是评价舒张功能障碍最准确的方法，但也有其自身的风险。本研究的目的是找出有创和无创参数之间的任何标准化相关性。这是一项观察性、描述性研究，共纳入500例患者。本研究的主要目的是确定超声心动图舒张参数与有创测量的左心室舒张末期压（LVEDP）之间的相关性。在研究不同侵入性和非侵入性数据的相关性时，据报道，E峰速度之间存在弱相关性，（r = 0.14，p = 0.631），A峰流速（r = 0.67，p = 0.59），IVRT（r =-0.35，p = 0.178），二尖瓣减速时间（DT）（r =-0.06，p = 0.842）、肺静脉收缩期峰值流量（r =-0.02，p = 0.966）和舒张期峰值流量（r = 0.47，p = 0.201）与LVEDP的关系。LVEDP升高与心房收缩时肺静脉和二尖瓣血流（A-Ard）的持续时间和左心室所有四个纵向节段的E/Ea之间存在良好的正相关性。以E/Ea< 8为界值，诊断LVEDP> 12 mmHg的敏感性和特异性分别为89%和90%，以侧向E/Ea ≥ 12、LAVI ≥34 mL/m2、Ard-Ad > 30 msec为界值，对HFpEF患者舒张功能障碍的诊断价值最高。侧位E/Ea ≥ 12、LAVI ≥34 mL/m2、Ard-Ad > 30 msec对HFpEF患者舒张功能障碍的诊断价值最高，且与有创测量的LVEDP具有良好的相关性。
Though invasive monitoring is the most accurate to estimate diastolic dysfunction but it has its own risk. The purpose of this study was to find out any standardized correlation between invasive and non -invasive parameters. It is an observational, descriptive study comprising of a total of 500 patients. The primary objective of the study was to determine the correlation between echocardiographic diastolic parameters and invasively measured left ventricular end diastolic pressure (LVEDP). On studying correlation of different invasive and non-invasive data it was reported that there was a weak correlation between peak E velocity (r = 0.14, p = 0.631), Peak A velocity (r = 0.67, p = 0.59), IVRT (r = −0.35, p = 0.178), Mitral deceleration time (DT) (r = −0.06, p = 0.842), pulmonary venous peak systolic (r = −0.02, p = 0.966) and diastolic flows (r = 0.47, p = 0.201) to LVEDP. There was a good positive correlation between elevated LVEDP and difference in duration of pulmonary venous and mitral flow at atrial contraction (A-Ard) and E/Ea at all four longitudinal segments of the left ventricle. The sensitivity and specificity for detecting an elevated LVEDP of more than 12 mm Hg, using a cut off value of E/Ea< 8, were 89% and 90%.Lateral E/Ea ≥ 12, LAVI ≥34 mL/m2, and Ard–Ad > 30 msec have the greatest diagnostic value for diagnosing diastolic dysfunction in HFpEF patients. Lateral E/Ea ≥ 12, LAVI ≥34 mL/m2, and Ard–Ad > 30 msec have the greatest diagnostic value for diagnosing diastolic dysfunction in HFpEF patients and have good correlation with invasively measured LVEDP.
登录
查看更多内容
影响因子：
6.2
作者：
Lancellotti, Patrizio;Galderisi, Maurizio;Popescu, Bogdan A.
通讯作者：
Popescu, Bogdan A.
影响因子：
18.2
作者：
Lindqvist, Per;Wikstroem, Gerhard;Waldenstroem, Anders
通讯作者：
Waldenstroem, Anders
影响因子：
4.2
作者：
Karakan, Sebnem;Inan, Bekir
通讯作者：
Inan, Bekir
影响因子：
4.6
作者：
Murad, Khalil;Kitzman, Dalane W.
通讯作者：
Kitzman, Dalane W.
DOI：
10.1590/1414-431x20209646
发表时间：
2020-01-01
影响因子：
2.3
作者：
Ma, Chao;Luo, Huan;Gao, Chengshan
通讯作者：
Gao, Chengshan