Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis.
Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis.
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DOI：
10.1007/s40615-020-00921-5
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发表时间：
2021-12
影响因子：
3.9
通讯作者：
Kok LT
中科院分区：
文献类型：
--
作者：
Raharja A;Tamara A;Kok LT
本文评估了种族是否是COVID-19疾病的独立预后不良因素。MEDLINE、EMBASE、科克伦、世卫组织COVID-19数据库（从开始到2020年6月15日）和medRxiv。没有语言限制。使用Newcastle-Ottawa量表（NOS）和GRADE框架评估偏倚风险和证据的确定性。PROSPERO CRD 42020188421。纳入了72篇文章（59项队列研究，17，950，989例受试者，13项生态学研究; 54项基于美国，15项基于英国; 41项同行评审）进行系统综述，45项进行荟萃分析。偏倚风险较低：中位数NOS 7/9（四分位数间距6-8）。与白色种族相比，黑人（RR：0.96 [95% CI：0.83-1.08]）和亚裔（RR：0.99 [0.85-1.16]）的未校正全因死亡率相似，但西班牙裔降低（RR：0.69 [0.57-0.84]）。黑人（HR：1.38 [1.09-1.75]）和亚裔（HR：1.42 [1.15-1.75]）的年龄和性别校正风险显著升高，但西班牙裔（RR：1.14 [0.93-1.40]）未发生。进一步校正合并症后，这些相关性减弱至无显著性：黑人（HR：0.95 [0.72-1.25]）;亚裔（HR：1.17 [0.84-1.63]）;西班牙裔（HR：0.94 [0.63-1.44]）。亚组分析显示，英国少数民族的结局存在更大差异的趋势，尤其是住院风险。该审查无法确认某个种族是COVID-19的独立不良预后因素。COVID-19结果的种族差异可能部分归因于某些种族的合并症发生率较高。在线版本包含补充材料，可通过10.1007/s40615-020-00921-5获得。
This article evaluates if ethnicity is an independent poor prognostic factor in COVID-19 disease. MEDLINE, EMBASE, Cochrane, WHO COVID-19 databases from inception to 15/06/2020 and medRxiv. No language restriction. Newcastle-Ottawa Scale (NOS) and GRADE framework were utilised to assess the risk of bias and certainty of evidence. PROSPERO CRD42020188421. Seventy-two articles (59 cohort studies with 17,950,989 participants, 13 ecological studies; 54 US-based, 15 UK-based; 41 peer-reviewed) were included for systematic review and 45 for meta-analyses. Risk of bias was low: median NOS 7 of 9 (interquartile range 6–8). Compared to White ethnicity, unadjusted all-cause mortality was similar in Black (RR: 0.96 [95% CI: 0.83–1.08]) and Asian (RR: 0.99 [0.85–1.16]) but reduced in Hispanic ethnicity (RR: 0.69 [0.57–0.84]). Age- and sex-adjusted risks were significantly elevated for Black (HR: 1.38 [1.09–1.75]) and Asian (HR: 1.42 [1.15–1.75]), but not for Hispanic (RR: 1.14 [0.93–1.40]). Further adjusting for comorbidities attenuated these associations to non-significance: Black (HR: 0.95 [0.72–1.25]); Asian (HR: 1.17 [0.84–1.63]); Hispanic (HR: 0.94 [0.63–1.44]). Subgroup analyses showed a trend towards greater disparity in outcomes for UK ethnic minorities, especially hospitalisation risk. This review could not confirm a certain ethnicity as an independent poor prognostic factor for COVID-19. Racial disparities in COVID-19 outcomes may be partially attributed to higher comorbidity rates in certain ethnicity. The online version contains supplementary material available at 10.1007/s40615-020-00921-5.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
DOI：
10.1007/s40615-020-00833-4
发表时间：
2020-09-01
影响因子：
3.9
作者：
Abedi, Vida;Olulana, Oluwaseyi;Zand, Ramin
通讯作者：
Zand, Ramin
影响因子：
11.1
作者：
Imam, Z.;Odish, F.;Halalau, A.
通讯作者：
Halalau, A.
影响因子：
6.9
作者：
Hajifathalian, Kaveh;Kumar, Sonal;Sharaiha, Reem Z.
通讯作者：
Sharaiha, Reem Z.
影响因子：
28.2
作者：
Galloway, James B.;Norton, Sam;Cantle, Fleur
通讯作者：
Cantle, Fleur