Nanostructured lipid carriers employing polyphenols as promising anticancer agents: Quality by design (QbD) approach.
Nanostructured lipid carriers employing polyphenols as promising anticancer agents: Quality by design (QbD) approach.
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纳米结构的脂质载体采用多酚作为有前途的抗癌剂：设计质量（QBD）方法。
DOI：
10.1016/j.ijpharm.2017.04.078
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发表时间：
2017-06-30
影响因子：
5.8
通讯作者：
Iyer AK
中科院分区：
文献类型：
--
作者：
Bhise K;Kashaw SK;Sau S;Iyer AK
癌症是全球主要的死亡原因之一。癌症治疗中有几个障碍，因为副作用限制了其使用。纳米颗粒药物递送系统已经在一系列科学研究中针对癌症进行了测试。近年来，纳米结构脂质载体（NLC）的研究由于其相对于第一代固体脂质纳米颗粒（SLN）的优势而引起了相当大的关注。NLC有助于用简单的药物装载方法有效地装载水溶性差的药物。最近，由于多酚在预防癌症中具有良好作用的证据，人们对多酚的兴趣越来越大。多酚是植物产生的次生代谢产物。已经报道了它们通过各种机制和减少肿瘤细胞质量在预防肿瘤发展中的作用。本文旨在综述NLC发展背后的科学以及多酚作为有前途的抗癌药物的作用。还解释了设计质量原则（QbD），其用于许多纳米颗粒（包括NLC）的制剂开发，如文献中所报道。该图显示了通过EPR效应通过渗漏的肿瘤脉管系统摄取NLC。
Cancer is one of the leading causes of death worldwide. There are several hurdles in cancer therapy because of side-effects which limits its usage. Nanoparticulate drug delivery systems have been tested against cancer in a range of scientific studies. In the recent years, advanced research on Nanostructured Lipid Carriers (NLCs) has garnered considerable attention owing to the advantages over their first-generation counterparts, Solid Lipid Nanoparticles (SLN). NLCs facilitate efficient loading of poorly water soluble drugs with simple methods of drug loading. Recently, there is an increased interest in polyphenols because of the evidence of their promising role in prevention of cancer. Polyphenols are produced as secondary metabolites by plants. Their role in prevention of development of tumors through variety of mechanisms and reduction of tumor cell mass has been reported. This article aims to review the science behind development of NLCs and role of polyphenols as promising anticancer agents. Principles of Quality by Design (QbD) have also been explained which are used in formulation-development of many nanoparticles, including NLCs, as reported in literature. Figure showing uptake of NLC through leaky tumor vasculature via EPR effect.
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