Therapeutic Effect of Mesenchymal Stem Cells in Ulcerative Colitis: A Review on Achievements and Challenges.
Therapeutic Effect of Mesenchymal Stem Cells in Ulcerative Colitis: A Review on Achievements and Challenges.
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间充质干细胞治疗溃疡性结肠炎的研究进展与挑战
DOI：
10.3390/jcm9123922
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发表时间：
2020-12-03
影响因子：
3.9
通讯作者：
Karimi-Busheri F
中科院分区：
文献类型：
--
作者：
Hosseini-Asl SK;Mehrabani D;Karimi-Busheri F
炎症性肠病(IBD)，包括克罗恩病(CD)和溃疡性结肠炎(UC)，在亚洲和伊朗仍呈上升趋势。尽管集中于症状控制的治疗环境有所改善，但在过去10年中，长期结肠切除术并没有减少。因此，临床迫切需要新的治疗方法来补充现有的治疗方法。间充质干细胞(MSCs)是一种具有免疫抑制作用的多能成体干细胞，针对IBD作为一种新的治疗策略。最近，它们在细胞移植中的应用受到了全球的关注，因为它们易于扩增，可以植入的活性范围很广，而且它们是肠道粘膜的家园。此外，MSCs能够分化为上皮细胞和其他细胞，直接促进UC黏膜损伤的修复。似乎有必要加深我们的理解，将MSCs作为对传统疗法无效的UC患者的一种有前途的治疗选择。本文就骨髓间充质干细胞在UC中的治疗作用作一综述，并对UC细胞移植的成就和挑战进行讨论。
The worldwide epidemiology of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), still shows an increasing trend in Asia and Iran. Despite an improvement in the treatment landscape focused on symptomatic control, long-term colectomies have not decreased over the last 10-year period. Thus, novel therapies are urgently needed in clinics to supplement the existing treatments. Mesenchymal stem cells (MSCs) are multipotent adult stem cells with immunosuppressive effects, targeting IBD as a new treatment strategy. They have recently received global attention for their use in cell transplantation due to their easy expansion and wide range of activities to be engrafted, and because they are home to the mucosa of the intestine. Moreover, MSCs are able to differentiate into epithelial and other cells that can directly promote repair in the mucosal damages in UC. It seems that there is a need to deepen our understanding to target MSCs as a promising treatment option for UC patients who are refractory to conventional therapies. Here, we overviewed the therapeutic effects of MSCs in UC and discussed the achievements and challenges in the cell transplantation of UC.
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