SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution.
SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution.
复制标题
SARS-COV-2感染增加了双峰年龄分布中急性肾脏损伤的风险。
DOI：
10.1186/s12882-022-02681-2
复制
发表时间：
2022-02-11
期刊：
影响因子：
2.3
通讯作者：
SCCM Discovery VIRUS Investigators Group
中科院分区：
文献类型：
--
作者：
Bjornstad EC;Cutter G;Guru P;Menon S;Aldana I;House S;M Tofil N;St Hill CA;Tarabichi Y;Banner-Goodspeed VM;Christie AB;Mohan SK;Sanghavi D;Mosier JM;Vadgaonkar G;Walkey AJ;Kashyap R;Kumar VK;Bansal V;Boman K;Sharma M;Bogojevic M;Deo N;Retford L;Gajic O;Gist KM;SCCM Discovery VIRUS Investigators Group
SARS-CoV 2住院患者经常发生急性肾损伤（阿基），但在理解为什么成人似乎比儿童有更高的发病率方面仍然存在差距。我们的目标是评估SARS-CoV 2相关阿基在不同年龄段的流行病学，并确定已知的风险因素（如疾病严重程度）是否对其模式有影响。正在进行的前瞻性国际队列登记研究的次要分析。阿基仅通过KDIGO-肌酐标准定义。对数线性、logistic和广义估计方程评估了阿基和死亡率的比值比（OR）、风险差异（RD）和95%置信区间（CI），并调整了性别、既存合并症、人种/种族、疾病严重程度和中心内聚集性。敏感性分析评估了不同的基线肌酐估计值。总体而言，在6874例住院患者中，39.6%（n = 2719）发生了阿基。阿基按年龄呈双峰分布，在老年（≥60岁）和儿童中期（5-15岁）达到峰值，尽管控制了疾病严重程度、既存合并症或不同的基线肌酐估计值，但这种分布仍持续存在。例如，SARS-CoV 2住院患者发生阿基的校正OR为2.74（95% CI 1.66-4.56），10-15岁与30-35岁相比，相似性为2.31（95%CI 1.71-3.12），而与30-35岁相比，40-45岁的调整后OR降至1.39（95%CI 0.97-2.00）。SARS-CoV 2相关的阿基常见于双峰年龄分布，已知的风险因素或混杂因素无法完全解释。随着大流行转向不成比例地影响年轻人，这值得进一步研究，因为阿基和SARS-CoV 2感染的存在增加了医院死亡风险。在线版本包含补充材料，可通过10.1186/s12882-022-02681-2获得。
Hospitalized patients with SARS-CoV2 develop acute kidney injury (AKI) frequently, yet gaps remain in understanding why adults seem to have higher rates compared to children. Our objectives were to evaluate the epidemiology of SARS-CoV2-related AKI across the age spectrum and determine if known risk factors such as illness severity contribute to its pattern. Secondary analysis of ongoing prospective international cohort registry. AKI was defined by KDIGO-creatinine only criteria. Log-linear, logistic and generalized estimating equations assessed odds ratios (OR), risk differences (RD), and 95% confidence intervals (CIs) for AKI and mortality adjusting for sex, pre-existing comorbidities, race/ethnicity, illness severity, and clustering within centers. Sensitivity analyses assessed different baseline creatinine estimators. Overall, among 6874 hospitalized patients, 39.6% (n = 2719) developed AKI. There was a bimodal distribution of AKI by age with peaks in older age (≥60 years) and middle childhood (5–15 years), which persisted despite controlling for illness severity, pre-existing comorbidities, or different baseline creatinine estimators. For example, the adjusted OR of developing AKI among hospitalized patients with SARS-CoV2 was 2.74 (95% CI 1.66–4.56) for 10–15-year-olds compared to 30–35-year-olds and similarly was 2.31 (95% CI 1.71–3.12) for 70–75-year-olds, while adjusted OR dropped to 1.39 (95% CI 0.97–2.00) for 40–45-year-olds compared to 30–35-year-olds. SARS-CoV2-related AKI is common with a bimodal age distribution that is not fully explained by known risk factors or confounders. As the pandemic turns to disproportionately impacting younger individuals, this deserves further investigation as the presence of AKI and SARS-CoV2 infection increases hospital mortality risk. The online version contains supplementary material available at 10.1186/s12882-022-02681-2.
登录
查看更多内容
DOI：
10.1056/nejmoa1611391
发表时间：
2017-01-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kaddourah A;Basu RK;Bagshaw SM;Goldstein SL;AWARE Investigators
通讯作者：
AWARE Investigators
影响因子：
8.8
作者：
Walkey AJ;Sheldrick RC;Kashyap R;Kumar VK;Boman K;Bolesta S;Zampieri FG;Bansal V;Harhay MO;Gajic O
通讯作者：
Gajic O
影响因子：
6
作者：
Hardenberg JB;Stockmann H;Aigner A;Gotthardt I;Enghard P;Hinze C;Balzer F;Schmidt D;Zickler D;Kruse J;Körner R;Stegemann M;Schneider T;Schumann M;Müller-Redetzky H;Angermair S;Budde K;Weber-Carstens S;Witzenrath M;Treskatsch S;Siegmund B;Spies C;Suttorp N;Rauch G;Eckardt KU;Schmidt-Ott KM
通讯作者：
Schmidt-Ott KM
DOI：
10.1053/j.ajkd.2020.12.007
发表时间：
2021-04
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Moledina DG;Simonov M;Yamamoto Y;Alausa J;Arora T;Biswas A;Cantley LG;Ghazi L;Greenberg JH;Hinchcliff M;Huang C;Mansour SG;Martin M;Peixoto A;Schulz W;Subair L;Testani JM;Ugwuowo U;Young P;Wilson FP
通讯作者：
Wilson FP
纽约市Covid-19危重疾病患者急性肾脏损伤的发生率降低。
影响因子：
6
作者：
Charytan DM;Parnia S;Khatri M;Petrilli CM;Jones S;Benstein J;Horwitz LI
通讯作者：
Horwitz LI