Metallothioneins: Emerging Modulators in Immunity and Infection.
Metallothioneins: Emerging Modulators in Immunity and Infection.
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DOI：
10.3390/ijms18102197
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发表时间：
2017-10-23
影响因子：
5.6
通讯作者：
Deepe GS Jr
中科院分区：
文献类型：
--
作者：
Subramanian Vignesh K;Deepe GS Jr
金属硫蛋白（Metallothioneins，MTs）是一个在原核生物、低等真核生物、无脊椎动物和哺乳动物中广泛表达的金属结合蛋白家族。这些蛋白质调节锌（Zn）和铜（Cu）的体内平衡，减轻重金属中毒，减轻超氧化物应激。近年来，MT已成为免疫系统的一个重要组成部分，但在很大程度上被低估。先天性和适应性免疫细胞调节MT响应于应激刺激、细胞因子信号和微生物挑战。这些细胞中MT的调节进而调节金属离子释放、转运和分布、细胞氧化还原状态、酶功能和细胞信号传导。虽然已经确定宿主在微生物发病过程中严格调节金属离子的可用性，但我们最近才开始解开金属调节途径和免疫防御之间的相互作用。从这个角度来看，利用MT的潜力来协调炎症反应和抗菌防御的机制的研究已经获得了动力。因此，本文综述的目的是阐明MT在免疫调节中的作用。我们讨论了免疫细胞中MT诱导和信号传导的机制，并探讨了MT-Zn轴在增强对病原体的免疫防御中的治疗潜力。
Metallothioneins (MTs) are a family of metal-binding proteins virtually expressed in all organisms including prokaryotes, lower eukaryotes, invertebrates and mammals. These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress. In recent years, MTs have emerged as an important, yet largely underappreciated, component of the immune system. Innate and adaptive immune cells regulate MTs in response to stress stimuli, cytokine signals and microbial challenge. Modulation of MTs in these cells in turn regulates metal ion release, transport and distribution, cellular redox status, enzyme function and cell signaling. While it is well established that the host strictly regulates availability of metal ions during microbial pathogenesis, we are only recently beginning to unravel the interplay between metal-regulatory pathways and immunological defenses. In this perspective, investigation of mechanisms that leverage the potential of MTs to orchestrate inflammatory responses and antimicrobial defenses has gained momentum. The purpose of this review, therefore, is to illumine the role of MTs in immune regulation. We discuss the mechanisms of MT induction and signaling in immune cells and explore the therapeutic potential of the MT-Zn axis in bolstering immune defenses against pathogens.
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影响因子：
120.7
作者：
CHANDRA, RK
通讯作者：
CHANDRA, RK
影响因子：
4.2
作者：
Davis, SR;McMahon, RJ;Cousins, RJ
通讯作者：
Cousins, RJ
DOI：
10.1152/ajpendo.1997.272.6.e1002
发表时间：
1997-06-01
影响因子：
5.1
作者：
Beck, FWJ;Prasad, AS;Brewer, GJ
通讯作者：
Brewer, GJ
IL-10受体信号传导对于体内TR1细胞功能至关重要。
DOI：
10.4049/jimmunol.1601045
发表时间：
2017-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brockmann L;Gagliani N;Steglich B;Giannou AD;Kempski J;Pelczar P;Geffken M;Mfarrej B;Huber F;Herkel J;Wan YY;Esplugues E;Battaglia M;Krebs CF;Flavell RA;Huber S
通讯作者：
Huber S
影响因子：
30.3
作者：
Botella H;Peyron P;Levillain F;Poincloux R;Poquet Y;Brandli I;Wang C;Tailleux L;Tilleul S;Charrière GM;Waddell SJ;Foti M;Lugo-Villarino G;Gao Q;Maridonneau-Parini I;Butcher PD;Castagnoli PR;Gicquel B;de Chastellier C;Neyrolles O
通讯作者：
Neyrolles O