Age-Related Anabolic Resistance of Myofibrillar Protein Synthesis Is Exacerbated in Obese Inactive Individuals.
Age-Related Anabolic Resistance of Myofibrillar Protein Synthesis Is Exacerbated in Obese Inactive Individuals.
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DOI：
10.1210/jc.2017-00869
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发表时间：
2017-09-01
期刊：
影响因子：
--
通讯作者：
Breen L
中科院分区：
文献类型：
--
作者：
Smeuninx B;Mckendry J;Wilson D;Martin U;Breen L
肌肉对蛋白质营养的合成代谢反应减弱可能是与年龄相关的肌肉损失的基础。确定时间和生物衰老如何影响肌原纤维蛋白合成 (MyoPS)。横截面比较。临床研究设施。十岁瘦身[OL: 71.7 ± 6 岁;体重指数 (BMI) ≤25 kg·m−2]、7 名老年肥胖者（OO：69.1 ± 2 岁；BMI ≥30 kg·m−2）和 18 名年轻瘦身 (YL) 个体（25.5 ± 4 岁；BMI ≤25 kg·m−2）。在连续灌注 L-[ring-13C6]-苯丙氨酸过程中获得的骨骼肌活检。人体测量学、胰岛素抵抗、炎症标志物、习惯饮食、体力活动、MyoPS 率和纤维类型特征。与 YL 和 OL 相比，OO 组的脂肪量、胰岛素抵抗、炎症和 II 型纤维肌细胞内脂质较多，每日步数较低。 YL 中餐后 MyoPS 率高于吸收后值约 81%（P < 0.001），OL 中约 38%（P = 0.002，与 YL 没有差异），OO 中约 9%（P = 0.11）。与 OL (P = 0.032) 和 OO (P < 0.001) 相比，YL 中餐后 MyoPS 与吸收后值的 Delta 变化更大。在老年人中，绝对餐后 MyoPS 发生率和 Delta 餐后 MyoPS 变化分别与步数（r2 = 0.33；P = 0.015）和腿部脂肪量（r2 = 0.4；P = 0.006）相关。矛盾的是，各组之间的瘦体重相似，并且 OO 组与 OL 组的肌纤维面积更大 (P = 0.002)。在肥胖且不活动的个体中，与年龄相关的肌肉合成代谢阻力会加剧，但对肌肉质量没有明显损害。我们研究了时间和生物衰老如何影响肌肉合成代谢，发现营养刺激的肌肉蛋白质合成率在肥胖、不活跃的老年人中受到损害。
A diminished muscle anabolic response to protein nutrition may underpin age-associated muscle loss. To determine how chronological and biological aging influence myofibrillar protein synthesis (MyoPS). Cross-sectional comparison. Clinical research facility. Ten older lean [OL: 71.7 ± 6 years; body mass index (BMI) ≤25 kg ⋅ m−2], 7 older obese (OO: 69.1 ± 2 years; BMI ≥30 kg ⋅ m−2), and 18 young lean (YL) individuals (25.5 ± 4 years; BMI ≤25 kg ⋅ m−2). Skeletal muscle biopsies obtained during a primed-continuous infusion of l-[ring-13C6]-phenylalanine. Anthropometrics, insulin resistance, inflammatory markers, habitual diet, physical activity, MyoPS rates, and fiber-type characteristics. Fat mass, insulin resistance, inflammation, and type II fiber intramyocellular lipid were greater, and daily step count lower, in OO compared with YL and OL. Postprandial MyoPS rates rose above postabsorptive values by ∼81% in YL (P < 0.001), ∼38% in OL (P = 0.002, not different from YL), and ∼9% in OO (P = 0.11). Delta change in postprandial MyoPS from postabsorptive values was greater in YL compared with OL (P = 0.032) and OO (P < 0.001). Absolute postprandial MyoPS rates and delta postprandial MyoPS change were associated with step count (r2 = 0.33; P = 0.015) and leg fat mass (r2 = 0.4; P = 0.006), respectively, in older individuals. Paradoxically, lean mass was similar between groups, and muscle fiber area was greater in OO vs OL (P = 0.002). Age-related muscle anabolic resistance is exacerbated in obese inactive individuals, with no apparent detriment to muscle mass. We studied how chronological and biological aging influence muscle anabolism and found that nutrient-stimulated muscle protein synthesis rates are impaired in obese, inactive older individuals.
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影响因子：
4.2
作者：
Ethgen O;Beaudart C;Buckinx F;Bruyère O;Reginster JY
通讯作者：
Reginster JY
DOI：
10.1093/gerona/glu103
发表时间：
2015-01-01
影响因子：
5.1
作者：
Moore, Daniel R.;Churchward-Venne, Tyler A.;Phillips, Stuart M.
通讯作者：
Phillips, Stuart M.
影响因子：
5.8
作者：
Goodpaster, BH;He, J;Kelley, DE
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Kelley, DE
影响因子：
4.5
作者：
Burd, Nicholas A;West, Daniel Wd;Phillips, Stuart M
通讯作者：
Phillips, Stuart M
影响因子：
6.7
作者：
Landi, Francesco;Cruz-Jentoft, Alfonso J.;Onder, Graziano
通讯作者：
Onder, Graziano