Comparative Monte Carlo study on the performance of integration- and list-mode detector configurations for carbon ion computed tomography
Comparative Monte Carlo study on the performance of integration- and list-mode detector configurations for carbon ion computed tomography
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碳离子计算机断层扫描积分模式和列表模式探测器配置性能的比较蒙特卡罗研究
DOI：
10.1088/1361-6560/aa5602
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发表时间：
2017
影响因子：
3.5
通讯作者：
Parodi K
中科院分区：
文献类型：
--
作者：
Meyer S;Gianoli C;Magallanes L;Kopp B;Tessonnier T;Landry G;Dedes G;Voss B;Parodi K
离子束治疗提供了一个高度适形的肿瘤剂量分布的可能性，然而，这种技术是非常敏感的治疗过程中的不准确性。治疗计划X射线CT的Hounsfield单位到相对阻止本领（RSP）的转换中的模糊性可导致估计的离子范围中的不确定性高达几毫米。离子CT（iCT）代表了一种有利的解决方案，允许直接评估RSP。在这项模拟研究中，我们研究了碳iCT的集成模式配置的性能，在相同的设置下，与单粒子的方法相比。实验探测器由61个充满空气的平行板电离室组成，与3 mm厚的PMMA吸收体交错。通过蒙特卡罗模拟，该设计被应用于获得组织等效材料的体模的iCT。进行了优化的采集参数，以减少剂量暴露，并评估了减少吸收体厚度的影响。为了克服存在横向组织异质性时积分模式检测的局限性，开发了一种使用检测器信号线性分解的专用后处理方法，并将其性能与列表模式采集进行了比较。对于当前设置，体模剂量可降低至30 mGy以下，图像质量仅略有下降。通过使用分解方法，得到了正确的组分识别和约2.0%的RSP精度提高。集成和列表模式的比较表明后者的图像质量略好，平均中值RSP误差分别低于1.8%和1.0%。随着吸收体厚度的减小，观察到RSP误差减小。总体而言，这些发现支持iCT用于低剂量RSP估计的潜力，表明具有专用后处理策略的积分模式探测器可以提供与列表模式配置相当的RSP准确度。
Ion beam therapy offers the possibility of a highly conformal tumor-dose distribution; however, this technique is extremely sensitive to inaccuracies in the treatment procedures. Ambiguities in the conversion of Hounsfield units of the treatment planning x-ray CT to relative stopping power (RSP) can cause uncertainties in the estimated ion range of up to several millimeters. Ion CT (iCT) represents a favorable solution allowing to directly assess the RSP. In this simulation study we investigate the performance of the integration-mode configuration for carbon iCT, in comparison with a single-particle approach under the same set-up. The experimental detector consists of a stack of 61 air-filled parallel-plate ionization chambers, interleaved with 3 mm thick PMMA absorbers. By means of Monte Carlo simulations, this design was applied to acquire iCTs of phantoms of tissue-equivalent materials. An optimization of the acquisition parameters was performed to reduce the dose exposure, and the implications of a reduced absorber thickness were assessed. In order to overcome limitations of integration-mode detection in the presence of lateral tissue heterogeneities a dedicated post-processing method using a linear decomposition of the detector signal was developed and its performance was compared to the list-mode acquisition. For the current set-up, the phantom dose could be reduced to below 30 mGy with only minor image quality degradation. By using the decomposition method a correct identification of the components and a RSP accuracy improvement of around 2.0% was obtained. The comparison of integration-and list-mode indicated a slightly better image quality of the latter, with an average median RSP error below 1.8% and 1.0%, respectively. With a decreased absorber thickness a reduced RSP error was observed. Overall, these findings support the potential of iCT for low dose RSP estimation, showing that integration-mode detectors with dedicated post-processing strategies can provide a RSP accuracy comparable to list-mode configurations.
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用于质子射线照相和断层扫描的集成模式探测器的空间分辨率增强
DOI：
--
发表时间：
2016
期刊：
影响因子：
--
作者：
C. Gianoli;S. Meyer;L. Magallanes;G. Dedes;G. Landry;R. Nijhuis;U. Ganswindt;C. Thieke;C. Belka;K. Parodi
通讯作者：
K. Parodi
影响因子：
19.7
作者：
WILSON, RR
通讯作者：
WILSON, RR
利用扫描技术快速测量带电粒子肿瘤治疗中 3D 深度剂量分布的剂量测定系统
DOI：
--
发表时间：
2000
期刊：
影响因子：
--
作者：
C. Brusasco;B. Voss;D. Schardt;M. Krämer;G. Kraft
通讯作者：
G. Kraft
使用测距望远镜进行碳离子扫描射线照相的实验研究
影响因子：
3.5
作者：
Rinaldi I;Brons S;Jäkel O;Voss B;Parodi K
通讯作者：
Parodi K
重离子射线照相和断层扫描。
DOI：
--
发表时间：
2014
期刊：
Physica medica (Testo stampato)
影响因子：
--
作者：
Katia Parodi
通讯作者：
Katia Parodi