A new role for muscle segment homeobox genes in mammalian embryonic diapause.
A new role for muscle segment homeobox genes in mammalian embryonic diapause.
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DOI：
10.1098/rsob.130035
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发表时间：
2013-04-24
期刊：
影响因子：
5.8
通讯作者：
Dey SK
中科院分区：
文献类型：
--
作者：
Cha J;Sun X;Bartos A;Fenelon J;Lefèvre P;Daikoku T;Shaw G;Maxson R;Murphy BD;Renfree MB;Dey SK
哺乳动物胚胎滞育是子宫内胚泡生长和代谢活动暂时停止的一种现象，同时随着胚泡的激活和着床而处于静止状态。这种生殖策略从分娩开始暂时分离受孕，直到环境或母体条件有利于母亲和新生儿的生存。子宫和胚胎暂时静止，维持囊胚存活，然后在随后的着床中恢复囊胚激活的潜在分子机制尚不清楚。本研究表明，作为一个古老且高度保守的同源盒基因家族的成员，Msx1或Msx2的子宫表达在三种不相关的哺乳动物物种滞育期间持续存在，随后随着囊胚激活和着床而迅速下调。子宫Msx1和Msx2失活小鼠无法实现滞育和再激活。值得注意的是，北美水貂和澳大利亚灰袋鼠的MSX1或MSX2表达模式与小鼠相似——它在滞育期间持续存在，并在囊胚激活和着床时迅速下调。来自小鼠研究的证据表明，Msx基因在滞育中的作用是通过Wnt5a介导的，Wnt5a是子宫Msx的已知转录靶点。这些研究提供了强有力的证据，表明Msx基因家族在胚胎滞育期间在子宫中构成了一个共同的保守分子介质，以提高女性的生殖适应性。
Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or maternal conditions are favourable for the survival of the mother and newborn. The underlying molecular mechanism by which the uterus and embryo temporarily achieve quiescence, maintain blastocyst survival and then resume blastocyst activation with subsequent implantation remains unknown. Here, we show that uterine expression of Msx1 or Msx2, members of an ancient, highly conserved homeobox gene family, persists in three unrelated mammalian species during diapause, followed by rapid downregulation with blastocyst activation and implantation. Mice with uterine inactivation of Msx1 and Msx2 fail to achieve diapause and reactivation. Remarkably, the North American mink and Australian tammar wallaby share similar expression patterns of MSX1 or MSX2 as in mice—it persists during diapause and is rapidly downregulated upon blastocyst activation and implantation. Evidence from mouse studies suggests that the effects of Msx genes in diapause are mediated through Wnt5a, a known transcriptional target of uterine Msx. These studies provide strong evidence that the Msx gene family constitutes a common conserved molecular mediator in the uterus during embryonic diapause to improve female reproductive fitness.
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影响因子：
4.8
作者：
Lefevre, Pavine L. C.;Palin, Marie-France;Murphy, Bruce D.
通讯作者：
Murphy, Bruce D.
影响因子：
82.9
作者：
Cha J;Sun X;Dey SK
通讯作者：
Dey SK
DOI：
10.1530/jrf.0.0660681
发表时间：
1982-01-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
COPP, AJ
通讯作者：
COPP, AJ
DOI：
10.1073/pnas.98.3.1047
发表时间：
2001-01-30
影响因子：
11.1
作者：
Paria, BC;Ma, WG;Hogan, BLM
通讯作者：
Hogan, BLM
影响因子：
--
作者：
Kirkham, WB
通讯作者：
Kirkham, WB