A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD.

A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD.
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DOI:
10.1002/oby.22964
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发表时间:
2020-10
期刊:
Obesity (Silver Spring, Md.)
影响因子:
--
通讯作者:
Rector RS
Rector RS
中科院分区:
其他
文献类型:
--
作者:
Moore MP;Cunningham RP;Dashek RJ;Mucinski JM;Rector RS

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非酒精性脂肪性肝病(NAFLD)是一个主要的健康问题,近年来其患病率有所增加,同时肥胖和其他代谢疾病的发病率也在上升。目前,没有FDA批准的NAFLD药物疗法,生活方式干预,包括减肥和运动,仍然是治疗的基石。控制饮食组成和饮食模式可能是NAFLD治疗的可持续方法。包括旧石器时代、生酮、地中海、高蛋白、植物性、低碳水化合物和间歇性禁食饮食在内的饮食策略由于其对代谢疾病的益处而变得越来越受欢迎。在这篇综述中,我们将重点介绍目前已知的这些流行的饮食方法在临床人群中的NAFLD管理机制的见解,从动物研究。我们还将确定关键的知识差距,以更好地为未来旨在治疗NAFLD的临床前和临床研究提供信息。
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and its prevalence has increased in recent years, concurrent with rising rates of obesity and other metabolic diseases. Currently, there are no FDA-approved pharmacological therapies for NAFLD, and lifestyle interventions, including weight loss and exercise, remain the cornerstones for treatment. Manipulating diet composition and eating patterns may be a sustainable approach to NAFLD treatment. Dietary strategies including Paleolithic, ketogenic, Mediterranean, high-protein, plant-based, low-carbohydrate, and intermittent fasting diets have become increasingly popular due to their purported benefits on metabolic disease. In this review, we will highlight what is currently known about these popular dietary approaches in the management of NAFLD in clinical populations with mechanistic insight from animal studies. We will also identify key knowledge gaps to better inform future preclinical and clinical studies aimed at the treatment of NAFLD.
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