Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl
Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl
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小鼠双同源盒基因的三个串联重复的基因组结构和表达谱的表征：Duxbl
DOI：
10.1002/dvdy.22210
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发表时间：
2010
影响因子：
2.5
通讯作者：
Sue
中科院分区：
文献类型：
--
作者：
Shey‐Lin Wu;Ming;Swee;H. Hsieh;Tz;Wei;Shineng Huang;Chun;Sue
We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl‐s. The amino acid sequences of Duxbl homeodomains are most similar to those of human DUX4 protein, associated with facioscapulohumeral muscular dystrophy. In adult tissues, Duxbl is predominantly expressed in female reproductive organs and eyes, and slightly expressed in brain and testes. During gonad development, Duxbl is expressed from embryonic to adult stages and specifically expressed in oocytes and spermatogonia. During embryonic development, Duxbl is transcribed in limbs and tail. However, Duxbl proteins were only detected in trunk and limb muscles and in elongated myocytes and myotubes. In C2C12 muscle cell line, Duxbl expression pattern is similar to differentiated marker gene, Myogenin, increased in expression from 2 days onward in differentiating medium. We suggest that Duxbl proteins play regulatory roles during myogenesis and reproductive developments. Developmental Dynamics 239:927–940, 2010. © 2010 Wiley‐Liss, Inc.
影响因子：
3.1
作者：
A. Ohtoshi;M. Justice;R. Behringer
通讯作者：
A. Ohtoshi;M. Justice;R. Behringer