Male, but not female, Sprague Dawley rats display enhanced fear learning following acute ethanol withdrawal (hangover).
Male, but not female, Sprague Dawley rats display enhanced fear learning following acute ethanol withdrawal (hangover).
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雄性而非雌性Sprague道利大鼠在急性乙醇戒断（宿醉）后表现出增强的恐惧学习。
DOI：
10.1016/j.pbb.2021.173229
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发表时间：
2021-09
影响因子：
3.6
通讯作者：
Deak, Terrence
中科院分区：
文献类型：
--
作者：
Marsland, Paige;Parrella, Allissa;Vore, Andrew S.;Barney, Thaddeus M.;Varlinskaya, Elena, I;Deak, Terrence
本研究调查了单剂量酒精（宿醉）对雄性和雌性Sprague Dawley大鼠恐惧条件反射的影响。在实验1中，雄性和雌性分别腹腔注射0或3.5 g/kg乙醇，然后在注射后24小时适应情境恐惧。从急性乙醇中退出增强了雄性条件冻结反应的表达，但在雌性中没有。实验2表明，在男性受试者中，在条件反射前24小时停用急性乙醇可增强情境恐惧条件反射，但对听觉暗示的恐惧条件反射没有作用。实验3，雄性和雌性大鼠分别给予3.5 g/kg乙醇，测定各时间点血乙醇浓度（BECs），测定乙醇清除率。雌性大鼠清除乙醇的速度高于雄性大鼠，雌性大鼠需要10小时，雄性大鼠需要14小时才能从体内清除乙醇。由于女性对乙醇的清除速度比男性快，在实验4中，女性在给药后18小时进行条件反射，以保持乙醇清除和恐惧条件反射之间的间隔与男性相似。在条件反射前18小时停用急性乙醇对情境恐惧和听觉恐惧条件反射均无影响。总之，这些结果突出了急性酒精（宿醉）戒断对恐惧学习影响的性别差异；这表明男性对宿醉带来的负面情绪的增强比女性更敏感。
The present studies investigated the effects of withdrawal from a single binge-like dose of ethanol (hangover) on fear conditioning in male and female Sprague Dawley rats. In Experiment 1, males and females were given 0 or 3.5 g/kg ethanol intraperitoneally (i.p.) and then conditioned to contextual fear 24 hr post injection. Withdrawal from acute ethanol enhanced expression of the conditioned freezing response in males, but not in females. Experiment 2 demonstrated that in males, withdrawal from acute ethanol administered 24 hr prior to conditioning enhanced contextual fear conditioning, but not auditory-cued fear conditioning. In Experiment 3, male and female rats were given 3.5 g/kg ethanol, and blood ethanol concentrations (BECs) were assessed at various time points for determination of ethanol clearance. Female rats cleared ethanol at a higher rate than males, with 10 hr required for females and 14 for males to eliminate ethanol from their systems. Because females cleared ethanol faster than males, in Experiment 4, females were conditioned 18 hr after ethanol administration to keep the interval between ethanol clearance and fear conditioning similar to that of males. Withdrawal from acute ethanol given 18 hr prior to conditioning did not affect both contextual and auditory-cued fear conditioning in females. In summary, these results highlight sex differences in the impact of withdrawal from acute ethanol (hangover) on fear learning; suggesting that males are more sensitive to hangover-associated enhancement of negative affect than females.
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乙醇暴露对提示和上下文恐惧条件和灭绝的后果因青春期或成年期暴露时间而有所不同。
影响因子：
2.7
作者：
Broadwater, Margaret;Spear, Linda P.
通讯作者：
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影响因子：
7.7
作者：
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影响因子：
15.8
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影响因子：
5.6
作者：
Eugenia Bertotto, Maria;Martina Maldonado, Noelia;Delia Martijena, Irene
通讯作者：
Delia Martijena, Irene
影响因子：
2.7
作者：
Bisby JA;King JA;Sulpizio V;Degeilh F;Valerie Curran H;Burgess N
通讯作者：
Burgess N