Consequences of ethanol exposure on cued and contextual fear conditioning and extinction differ depending on timing of exposure during adolescence or adulthood.
Consequences of ethanol exposure on cued and contextual fear conditioning and extinction differ depending on timing of exposure during adolescence or adulthood.
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乙醇暴露对提示和上下文恐惧条件和灭绝的后果因青春期或成年期暴露时间而有所不同。
DOI：
10.1016/j.bbr.2013.08.013
复制
发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Spear, Linda P.
中科院分区：
文献类型：
--
作者：
Broadwater, Margaret;Spear, Linda P.
一些证据表明，青少年比成年人更敏感，乙醇引起的认知缺陷，这些影响可能是持久的。实验1的目的是确定早期-中期青少年[出生后第28-48天（P）]间歇性乙醇暴露是否会影响巴甫洛夫恐惧条件反射范式中的后期学习和记忆，与成年期的类似暴露不同（P70-90）。在实验2中，动物在青春期中后期（P35-55）暴露于乙醇，以评估青春期内的起始年龄是否会对学习和记忆产生差异性影响。雄性Sprague-Dawley大鼠以4g/kg i.g.乙醇（25%）或水，每48小时一次，共暴露11次。在22天的非乙醇期后，将动物恐惧条件化到背景（相对的视皮层依赖性任务）或音调（杏仁核依赖性任务），然后进行保留测试和该条件化的消退（mPFC依赖性）。尽管类似的收购，赤字的背景下恐惧保留是明显的，在青春期早期暴露于乙醇的动物，在青春期中后期或成年期的可比乙醇暴露后没有观察到的效果。相反，在青春期中后期或成年期暴露于乙醇的动物表现出对环境灭绝的抵抗力增强。总之，这些发现表明，重复的乙醇对学习和记忆产生了持久的影响，结果取决于暴露的年龄。这些结果可能反映了乙醇对大脑的不同影响，因为它在整个个体发育过程中发生变化，并可能对酒精的使用产生影响，不仅在整个青春期的发育阶段，而且在成年期。
Some evidence suggests that adolescents are more sensitive than adults to ethanol-induced cognitive deficits and that these effects may be long-lasting. The purpose of Exp 1 was to determine if early-mid adolescent [Postnatal day (P) 28-48] intermittent ethanol exposure would affect later learning and memory in a Pavlovian fear conditioning paradigm differently than comparable exposures in adulthood (P70-90). In Exp 2 animals were exposed to ethanol during mid-late adolescence (P35-55) to assess whether age of initiation within the adolescent period would influence learning and memory differentially. Male Sprague-Dawley rats were given 4 g/kg i.g. ethanol (25%) or water every 48 hours for a total of 11 exposures. After a 22 day non-ethanol period, animals were fear conditioned to a context (relatively hippocampal-dependent task) or tone (amygdala-dependent task), followed by retention tests and extinction (mPFC-dependent) of this conditioning. Despite similar acquisition, a deficit in context fear retention was evident in animals exposed to ethanol in early adolescence, an effect not observed after a comparable ethanol exposure in mid-late adolescence or adulthood. In contrast, animals that were exposed to ethanol in mid-late adolescence or adulthood showed enhanced resistance to context extinction. Together these findings suggest that repeated ethanol imparts long-lasting consequences on learning and memory, with outcomes that differ depending on age of exposure. These results may reflect differential influence of ethanol on the brain as it changes throughout ontogeny and may have implications for alcohol use not only throughout the developmental period of adolescence, but also in adulthood.
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青少年暴饮暴食改变了小鼠的成人脑神经递质的表达，行为，大脑区域体积和神经化学。
DOI：
10.1111/j.1530-0277.2010.01385.x
发表时间：
2011-04
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
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通讯作者：
Crews FT
影响因子：
7.6
作者：
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通讯作者：
Laviola, G
影响因子：
1.9
作者：
Cabrera, SM;Chavez, CM;Butt, AE
通讯作者：
Butt, AE
影响因子：
5.3
作者：
Fischer, A;Sananbenesi, F;Radulovic, J
通讯作者：
Radulovic, J
影响因子：
2.5
作者：
Cunningham, MG;Bhattacharyya, S;Benes, FM
通讯作者：
Benes, FM