Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.
Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.
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DOI：
10.1038/s41598-021-93918-x
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发表时间：
2021-07-15
影响因子：
4.6
通讯作者：
Reeves RK
中科院分区：
文献类型：
--
作者：
Jones R;Kroll K;Broedlow C;Schifanella L;Smith S;Hueber B;Shah SV;Ram DR;Manickam C;Varner V;Klatt NR;Reeves RK
HIV/SIV 感染导致粘膜 CD4+T 细胞大量损失和上皮粘膜破裂，导致严重的微生物失调和慢性免疫激活，最终推动疾病进展。此外，在 HIV 诱导的免疫抑制过程中，对研究最多的粘膜环境之一（口腔）的破坏会导致显着的微生物和肿瘤并发症，并导致和预测远端疾病并发症。在这项研究中，我们评估了口服益生菌补充剂 (PBX) 对恒河猴早期 SIV 感染的影响，它可以刺激和增强炎症或抗炎途径。我们的研究表明，与胃肠道粘膜类似，口腔 CD4++T 细胞迅速耗尽，作为对 SIV 感染中口腔微生物群落的首次全面分析之一，我们还在感染后早期观察到卟啉单胞菌属和放线杆菌属两个属之间的显着调节。有趣的是，尽管 PBX 疗法并不能显着防止口腔生态失调或改善细胞损失，但它确实在一定程度上抑制了炎症和 T 细胞活化。总的来说，这些数据提供了对 SIV 诱导的口腔微生物组和 CD4++T 细胞群变化的最全面的评估之一，并且还表明口腔 PBX 可能在慢病毒感染中具有一些抗炎特性。
HIV/SIV infections lead to massive loss of mucosal CD4 + T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of one of the most understudied mucosal environments, the oral cavity, during HIV-induced immunosuppression results in significant microbial and neoplastic co-morbidities and contributes to and predicts distal disease complications. In this study we evaluated the effects of oral probiotic supplementation (PBX), which can stimulate and augment inflammatory or anti-inflammatory pathways, on early SIV infection of rhesus macaques. Our study revealed that similar to the GI mucosae, oral CD4 + T cells were rapidly depleted, and as one of the first comprehensive analyses of the oral microflora in SIV infection, we also observed significant modulation among two genera, Porphyromonas and Actinobacillus, early after infection. Interestingly, although PBX therapy did not substantially protect against oral dysbiosis or ameliorate cell loss, it did somewhat dampen inflammation and T cell activation. Collectively, these data provide one of the most comprehensive evaluations of SIV-induced changes in oral microbiome and CD4 + T cell populations, and also suggest that oral PBX may have some anti-inflammatory properties in lentivirus infections.
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影响因子：
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