IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.
IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.
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DOI：
10.4049/jimmunol.0902542
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发表时间：
2010-04-01
期刊：
影响因子：
--
通讯作者：
Ganea D
中科院分区：
文献类型：
--
作者：
Yen JH;Kong W;Ganea D
Interferon β (IFNβ) is an approved therapeutic option for the treatment of multiple sclerosis (MS). The molecular mechanisms underlying the effects of IFNβ in MS are not fully understood. Migration of dendritic cells (DC) from the inflammatory site to draining lymph nodes for antigen presentation and activation of naïve T cells, and to the CNS for reactivation of encephalitogenic T cells, requires CCR7 and MMP-9 expression. Here we report for the first time that IFNβ inhibits CCR7 expression and MMP-9 production in mature DC, and reduces their migratory capacity. The effect of IFNβ is mediated through STAT-1. In vivo treatment with IFNβ results in lower numbers of DC migrating to the draining lymph node following exposure to FITC, and in reduced expression of CCR7 and MMP-9 in splenic CD11c+ DC following LPS administration. IFNβ and IFNγ share the same properties in terms of effects on CCR7, MMP-9 and DC migration, but have opposite effects on IL-12 production. In addition, IFNβ-treated DC have a significantly reduced capacity for activating CD4+ T cells and generating IFNγ-producing Th1 cells. The suppression of mature DC migration through negative regulation of CCR7 and MMP-9 expression represents a novel mechanism for the therapeutic effect of IFNβ.
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DOI：
10.1097/nen.0b013e31816fc975
发表时间：
2008-05-01
影响因子：
3.2
作者：
Lande, Roberto;Gafa, Valerie;Coccia, Eliana Marina
通讯作者：
Coccia, Eliana Marina
DOI：
10.1084/jem.166.6.1654
发表时间：
1987-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Macatonia SE;Knight SC;Edwards AJ;Griffiths S;Fryer P
通讯作者：
Fryer P
影响因子：
5.5
作者：
Alder, John;Hahn-Zoric, Mirjana;Karlsson-Parra, Alex
通讯作者：
Karlsson-Parra, Alex
影响因子：
3.6
作者：
Martin-Saavedra, Francisco M.;Gonzalez-Garcia, Coral;Ballester, Sara
通讯作者：
Ballester, Sara
影响因子：
11.4
作者：
Knoedler, A.;Schmidt, S. M.;Brossart, P.
通讯作者：
Brossart, P.