Intrathecal veratridine administration increases minimum alveolar concentration in rats.
Intrathecal veratridine administration increases minimum alveolar concentration in rats.
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DOI：
10.1213/ane.0b013e3181815fbc
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发表时间：
2008-09
影响因子：
5.7
通讯作者：
Harris RA
中科院分区：
文献类型：
--
作者：
Zhang Y;Sharma M;Eger EI 2nd;Laster MJ;Hemmings HC Jr;Harris RA
多项研究的结果表明钠通道是吸入麻醉剂产生的不动的潜在介质。我们假设鞘内注射藜芦定（一种增强钠通道活性或作用的药物）应该会增加 MAC。我们测量了大鼠腰胸蛛网膜下腔鞘内注射不同浓度藜芦碱引起的异氟烷MAC的变化。我们将这些结果与脑室内输注获得的结果进行了比较。正如预测的那样，鞘内输注藜芦定会增加 MAC。最大输注浓度（25 μM）也会对两只大鼠的后肢产生神经元损伤，并降低对 MAC 的峰值效应。 1.6 μM 的浓度使 MAC 增加最大（21%）。脑室内输注 1.6 和 6.4 μM 藜芦碱不会改变 MAC。给予 25 μM 的大鼠死亡。鞘内注射藜芦定会增加异氟烷的 MAC，这一发现与钠通道作为吸入麻醉剂产生的不动性的潜在介质的作用一致。鞘内注射藜芦定可增加 MAC，可能是通过对钠通道的影响。
Results from several studies point to sodium channels as potential mediators of the immobility produced by inhaled anesthetics. We hypothesized that the intrathecal administration of veratridine, a drug that enhances the activity or effect of sodium channels, should increase MAC. We measured the change in isoflurane MAC caused by intrathecal infusion of various concentrations of veratridine into the lumbothoracic subarachnoid space of rats. We compared these result to those obtained from intracerebroventricular infusion. As predicted, intrathecal infusion of veratridine increased MAC. The greatest infused concentration (25 μM) also produced neuronal injury in the hind limbs of two rats and decreased the peak effect on MAC. A concentration of 1.6 μM produced the greatest (21%) increase in MAC. Intraventricular infusion of 1.6 and 6.4 μM veratridine did not alter MAC. Rats given 25 μM died. Intrathecal administration of veratradine increases MAC of isoflurane, a finding consistent with a role for sodium channels as potential mediators of the immobility produced by inhaled anesthetics. Intrathecal administration of veratridine can increase MAC, presumably by an effect on sodium channels.
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影响因子：
5.7
作者：
Laster, Michael J.;Zhang, Yi;Sonner, James M.
通讯作者：
Sonner, James M.
影响因子：
8.8
作者：
Lingamaneni, R;Birch, ML;Hemmings, HC
通讯作者：
Hemmings, HC
影响因子：
5.7
作者：
Zhang, Yi;Laster, Michael J.;Sonner, James M.
通讯作者：
Sonner, James M.
DOI：
10.1006/bbrc.1994.1373
发表时间：
1994-03-30
影响因子：
3.1
作者：
CORBETT, AM;VANDERKLOK, MA
通讯作者：
VANDERKLOK, MA
影响因子：
8.8
作者：
Ratnakumari, L;Hemmings, HC
通讯作者：
Hemmings, HC