The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase.
The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase.
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DOI：
10.3390/ijms18071541
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发表时间：
2017-07-17
影响因子：
5.6
通讯作者：
Steinhauer DA
中科院分区：
文献类型：
--
作者：
Byrd-Leotis L;Cummings RD;Steinhauer DA
甲型流感病毒的血凝素(HA)和神经氨酸酶(NA)糖蛋白负责病毒粒子与宿主的表面相互作用。病毒的进入是由HA的功能介导的：与细胞受体结合，促进病毒粒子膜与内体膜的融合。HA结构在三聚体的球状膜远端头域含有受体结合部位，融合机制位于茎区域。这些地点具有与亚型和宿主相关的特定特征，这些差异通常定义了物种障碍。例如，禽类病毒优先识别α2，3-唾液酸终止多糖作为受体，哺乳动物病毒识别α2，6-唾液酸。神经氨酸酶，或受体破坏蛋白，从细胞膜成分和病毒糖蛋白中裂解唾液酸，允许新生的病毒粒子排出。两种糖蛋白之间的功能活性平衡已被证明，导致最佳水平的HA亲和力和NA酶裂解，以允许生产性感染。随着对HA和NA的更多了解，HA和NA之间的功能平衡的相关性继续扩大，这可能对物种间传播、宿主适应和致病性产生影响。
The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of influenza A virus are responsible for the surface interactions of the virion with the host. Entry of the virus is mediated by functions of the HA: binding to cellular receptors and facilitating fusion of the virion membrane with the endosomal membrane. The HA structure contains receptor binding sites in the globular membrane distal head domains of the trimer, and the fusion machinery resides in the stem region. These sites have specific characteristics associated with subtype and host, and the differences often define species barriers. For example, avian viruses preferentially recognize α2,3-Sialic acid terminating glycans as receptors and mammalian viruses recognize α2,6-Sialic acid. The neuraminidase, or the receptor-destroying protein, cleaves the sialic acid from cellular membrane constituents and viral glycoproteins allowing for egress of nascent virions. A functional balance of activity has been demonstrated between the two glycoproteins, resulting in an optimum level of HA affinity and NA enzymatic cleavage to allow for productive infection. As more is understood about both HA and NA, the relevance for functional balance between HA and NA continues to expand, with potential implications for interspecies transmission, host adaptation, and pathogenicity.
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DOI：
10.1126/science.1223012
发表时间：
2012-08-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Button B;Cai LH;Ehre C;Kesimer M;Hill DB;Sheehan JK;Boucher RC;Rubinstein M
通讯作者：
Rubinstein M
影响因子：
5.6
作者：
BOSSARTWHITAKER, P;CARSON, M;AIR, GM
通讯作者：
AIR, GM
DOI：
10.1074/jbc.m110.115998
发表时间：
2010-10-29
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bateman AC;Karamanska R;Busch MG;Dell A;Olsen CW;Haslam SM
通讯作者：
Haslam SM
影响因子：
3.7
作者：
Bradley, Konrad C.;Jones, Cheryl A.;Steinhauer, David A.
通讯作者：
Steinhauer, David A.
影响因子：
5.4
作者：
Bradley, Konrad C.;Galloway, Summer E.;Steinhauer, David A.
通讯作者：
Steinhauer, David A.