Effect of traumatic event reexposure and PTSD on substance use disorder treatment response.
Effect of traumatic event reexposure and PTSD on substance use disorder treatment response.
复制标题
DOI：
10.1016/j.drugalcdep.2015.11.006
复制
发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Kidorf MS
中科院分区：
文献类型：
--
作者：
Peirce JM;Brooner RK;King VL;Kidorf MS
在以社区为基础的药物使用者中，创伤性事件再暴露的比率非常高，这对他们的物质使用障碍(SUD)产生了负面影响。治疗中这种再暴露的速度和效果尚不清楚。尽管越来越多的证据表明，创伤后应激障碍(PTSD)的诊断对长期SUD治疗结果的影响很小，但PTSD症状的波动可能会产生影响。这项前瞻性的纵向研究调查了169名男性和女性美沙酮维持患者的创伤事件再暴露和创伤后应激障碍症状的发生率和效果，这些患者都患有共病的精神障碍，他们参加了一项父母研究。在同一个月、一个月后和两个月后，测试创伤事件和创伤后应激障碍症状与药物使用、治疗中断和咨询依从性的关系。在这项为期12个月的研究中，大约18%的患者每月都会再次暴露在创伤性事件中。在同一个月和一个月后，再次暴露与治疗中断的风险大约是两倍。创伤后应激障碍症状严重程度每增加10%，两个月后治疗中断的风险增加36%。没有看到对药物使用或咨询依从性的影响。SUD患者创伤性事件再暴露率较高。创伤事件和创伤后应激障碍症状都与治疗中断的风险增加有关，导致SUD患者在他们可以从治疗支持中受益的时间离开治疗。
A remarkably high rate of traumatic event reexposure has been demonstrated in community-based substance users which negatively impacts their substance use disorder (SUD). The rate and effect of such reexposure in treatment is unknown. Despite increasing evidence that a diagnosis of posttraumatic stress disorder (PTSD) has little influence on long-term SUD treatment outcomes, it is possible that PTSD symptom fluctuations could have effects. This prospective longitudinal study examined the rate and effect of traumatic event reexposure and PTSD symptoms in 169 male and female methadone maintenance patients with a comorbid psychiatric disorder who were participating in a parent study. Traumatic events and PTSD symptoms were tested for association with drug use, treatment interruption, and counseling adherence in the same month, one month later, and two months later. Approximately 18% of patients were reexposed to a traumatic event each month during the 12-month study. Reexposure was associated with about twice the risk of treatment interruption in the same month and one month later. Every 10% increase in PTSD symptom severity was associated with a 36% increased risk of treatment interruption two months later. No effects were seen on drug use or counseling adherence. SUD patients have a relatively high rate of traumatic event reexposure. Both traumatic events and PTSD symptoms are associated with increased risk of treatment interruption, resulting in SUD patients leaving treatment at precisely the time they could benefit from treatment support.
社区注射器交换参与者再次暴露创伤事件的前瞻性危险因素。
影响因子：
4.2
作者：
Peirce, Jessica M.;Schacht, Rebecca L.;Brooner, Robert K.;King, Van L.;Kidorf, Michael S.
通讯作者：
Kidorf, Michael S.