Neurotransmitter corelease: mechanism and physiological role.
Neurotransmitter corelease: mechanism and physiological role.
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DOI:
10.1146/annurev-physiol-020911-153315
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发表时间:
2012
影响因子:
18.2
通讯作者:
Edwards RH
中科院分区:
文献类型:
--
作者:
Hnasko TS;Edwards RH
Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but it has become clear that many neurons in fact release multiple transmitters. Although the physiological role for co-release has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H+ electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Co-release thus serves multiple roles in synaptic transmission.
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