Neurotransmitter corelease: mechanism and physiological role.

Neurotransmitter corelease: mechanism and physiological role.
复制标题

DOI:
10.1146/annurev-physiol-020911-153315
复制
发表时间:
2012
影响因子:
18.2
通讯作者:
Edwards RH
Edwards RH
中科院分区:
医学1区
文献类型:
--
作者:
Hnasko TS;Edwards RH

文献摘要

参考文献

被引文献

相似文献

神经递质同一性是所有神经元的一个决定性特征,因为它限制了它们传递的信息类型,但很明显,许多神经元实际上释放多种递质。虽然共同释放的生理作用仍不清楚,但一种递质的囊泡摄取可以通过影响H+电化学驱动力的表达来调节另一种递质的填充。此外,囊泡神经递质转运体和其他突触囊泡蛋白在不同囊泡池中的分选表明可能存在不同的释放模式。因此,共释放在突触传递中起着多重作用。
Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but it has become clear that many neurons in fact release multiple transmitters. Although the physiological role for co-release has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H+ electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Co-release thus serves multiple roles in synaptic transmission.
DOI: 10.1038/nature06907
发表时间: 2008-06-05
期刊: NATURE
影响因子: 64.8
作者:
Graves, Austin R.;Curran, Patricia K.;Mindell, Joseph A.
通讯作者: Mindell, Joseph A.
DOI: 10.1523/jneurosci.4317-03.2004
发表时间: 2004-01-28
影响因子: 5.3
作者:
Chuhma, N;Zhang, H;Rayport, S
通讯作者: Rayport, S
DOI: 10.1073/pnas.0910986107
发表时间: 2010-01-05
影响因子: 11.1
作者:
Birgner, Carolina;Nordenankar, Karin;Wallen-Mackenzie, Asa
通讯作者: Wallen-Mackenzie, Asa
DOI: 10.1523/jneurosci.4074-09.2010
发表时间: 2010-01-06
影响因子: 5.3
作者:
Gronborg, Mads;Pavlos, Nathan J.;Jahn, Reinhard
通讯作者: Jahn, Reinhard
DOI: 10.1073/pnas.93.11.5347
发表时间: 1996-05-28
影响因子: 11.1
作者:
Busch, AE;Schuster, A;Lang, F
通讯作者: Lang, F