Dysregulated expression of T cell immunoglobulin and mucin domain 3 is associated with the disease severity and the outcome of patients with spontaneous intracerebral hemorrhage.
Dysregulated expression of T cell immunoglobulin and mucin domain 3 is associated with the disease severity and the outcome of patients with spontaneous intracerebral hemorrhage.
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T 细胞免疫球蛋白和粘蛋白结构域 3 的表达失调与自发性脑出血患者的疾病严重程度和预后相关
DOI：
10.1016/j.clinbiochem.2013.04.030
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发表时间：
2013-10
影响因子：
2.8
通讯作者：
Ma C
中科院分区：
文献类型：
--
作者：
Liu X;You J;Zhao D;Guo M;Pan Y;Gao L;Liang X;Ma C
目的探讨自发性脑出血（ICH）患者外周血T细胞免疫球蛋白和粘蛋白结构域3（Tim-3）的表达及其临床意义。采用流式细胞术检测脑出血患者和健康志愿者外周血免疫细胞Tim-3的表达。Tim-3表达与临床指标之间的相关性使用线性回归进行估计。脑出血患者外周血CD 3 + T细胞和CD 8 + T细胞的Tim-3表达明显下调，而CD 14+单核细胞和CD 16 + CD 56 + NK细胞的Tim-3表达明显上调。外周血CD8 + T细胞Tim-3表达与脑出血患者的炎症反应、病情严重程度及预后呈负相关。Tim-3的表达与血糖浓度无关。Tim-3的表达改变可能在脑出血的发病机制中起重要作用，提示Tim-3可能成为脑出血患者预后评估的新的候选分子。脑出血患者外周血细胞Tim-3表达失调。Tim-3在CD8 + T细胞上的表达与疾病的严重程度呈负相关。Tim-3在CD8 + T细胞上的表达与患者的预后呈负相关。
We aimed to investigate the expression of T cell immunoglobulin and mucin domain 3 (Tim-3) on peripheral blood cells in spontaneous intracerebral hemorrhage (ICH) patients and to analyze its clinical significance. Tim-3 expression on peripheral immunocytes from ICH patients and healthy volunteers was measured by flow cytometry. The correlation between Tim-3 expression and the clinical indices was estimated using linear regression. Tim-3 expressions on peripheral CD3+ T cells and CD8+ T cells in ICH patients are significantly downregulated, while Tim-3 expressions on CD14+ monocytes and CD16+CD56+ NK cells are increased. Furthermore, Tim-3 expression on peripheral CD8+ T cells was negatively correlated with the inflammatory response, the disease severity and the outcome of ICH patients. However, there was no relationship between Tim-3 expression and blood glucose concentration. Altered expression of Tim-3 might play an important role in the pathogenesis of ICH, demonstrating that Tim-3 might be a novel candidate molecule for prognosis evaluation of ICH patients. Tim-3 expression on peripheral blood cells in ICH patient was dysregulated. Tim-3 expression on CD8+ T cells negatively correlated with the disease severity. Tim-3 expression on CD8+ T cells negatively correlated with the patients' outcome.
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影响因子：
16.8
作者：
Sakuishi K;Jayaraman P;Behar SM;Anderson AC;Kuchroo VK
通讯作者：
Kuchroo VK
影响因子：
4.4
作者：
Oikawa, Tsunekazu;Kamimura, Yosuke;Azuma, Miyuki
通讯作者：
Azuma, Miyuki
影响因子：
8.3
作者：
Bejot, Yannick;Aboa-Eboule, Corine;Giroud, Maurice
通讯作者：
Giroud, Maurice
影响因子：
8.3
作者：
LEE, MC;HEANEY, LM;KLASSEN, AC
通讯作者：
KLASSEN, AC
影响因子：
168.9
作者：
Qureshi, Adnan I.;Mendelow, A. David;Hanley, Daniel F.
通讯作者：
Hanley, Daniel F.