Rotating Night Shift Work and Healthy Aging After 24 Years of Follow-up in the Nurses' Health Study.
Rotating Night Shift Work and Healthy Aging After 24 Years of Follow-up in the Nurses' Health Study.
复制标题
护士健康研究中24年随访后的轮班工作和健康老龄化。
DOI：
10.1001/jamanetworkopen.2022.10450
复制
发表时间：
2022-05-02
影响因子：
13.8
通讯作者：
Wang M
中科院分区：
文献类型：
--
作者：
Shi H;Huang T;Schernhammer ES;Sun Q;Wang M
轮值夜班工作是否与同时考虑慢性病、认知和身体功能以及心理健康的健康老龄化有关？在一项对46名 318名女护士进行的大型队列研究中，长期轮值夜班工作与24年后健康老龄化的几率略有下降有关。除了现有的文献表明倒班工作与死亡率增加有关外，这项研究的发现还进一步表明，倒班工作还与活到较高年龄的女性的整体健康状况较差有关。这项针对女护士的队列研究在《护士健康研究》中进行了24年的跟踪调查后，调查了轮值夜班工作与健康老龄化之间的关系。轮值夜班工作与更高的死亡率有关。目前尚不清楚它是否也与那些活到较高年龄的人的整体健康有关。在护士健康研究中，对注册女护士进行了24年的队列研究，以检验轮值夜班工作是否与健康老龄化有关。在这项队列研究中，在1988年评估夜班工作史时，46名年龄在46~68岁、无重大慢性病的 318参与者中确定了一种复合型健康衰老表型。在第二次分析中，认知功能下降被考虑到健康老龄化的定义中，14名 273名护士参与其中。对2021年3月1日至9月30日的数据进行了分析。轮值夜班工作的持续时间。健康老龄化的定义是至少达到70岁，没有11种主要慢性病、记忆障碍、身体限制或精神健康恶化。在46名 318名女护士(基线平均年龄为55.4 [6.1]岁)中，3695名(8.0%)在24年后实现了健康老龄化。在调整了已有的和潜在的混杂因素后，与从未轮值夜班的女性相比，实现健康老龄化的几率随着夜班工作时间的增加而显著下降。1~5年、6~9年和10年以上夜班工作的OR值分别为0.96(95%CI，0.89~1.03)、0.92(95%CI，0.79~1.07)和0.79(95%CI，0.69~0.91)(趋势P = .001)。这种关联在年龄和生活方式上没有显著差异，并且在健康老龄化的四个个人维度上是一致的。二次分析的结果类似，有10年或10年以上夜班工作与没有夜班工作的优势比为0.73(95%可信区间为0.60-0.89；趋势为P <； .001)。在这项队列研究中，轮值夜班工作与降低美国女护士健康老龄化的可能性有关。这些数据支持这样一种观点，即过多的夜班工作是一个重大的健康问题，也可能导致老年人整体健康状况恶化。
Is rotating night shift work prospectively associated with healthy aging that simultaneously considers chronic diseases, cognitive and physical function, and mental health? In a large cohort study of 46 318 female nurses, long-term rotating night shift work was associated with modestly decreased odds of healthy aging after 24 years of follow-up. In addition to the existing literature suggesting that shift work is associated with increased mortality, the findings of this study further suggest that shift work is also associated with worse overall health among women who survive to older ages. This cohort study of female nurses examines the association between rotating night shift work and healthy aging after 24 years of follow-up in the Nurses’ Health Study. Rotating night shift work is associated with higher mortality. Whether it is also associated with overall health among those who survive to older ages remains unclear. To examine whether rotating night shift work is associated with healthy aging after 24 years of follow-up in the Nurses’ Health Study, a cohort study among registered female nurses. For this cohort study, a composite healthy aging phenotype was ascertained among 46 318 participants who were aged 46 to 68 years and free of major chronic diseases in 1988 when the history of night shift work was assessed. In a secondary analysis in which cognitive function decline was considered in the healthy aging definition, 14 273 nurses were involved. Data were analyzed from March 1 to September 30, 2021. Duration of rotating night shift work. Healthy aging was defined as reaching at least 70 years of age and being free of 11 major chronic diseases, memory impairment, physical limitation, or deteriorated mental health. Of 46 318 female nurses (mean [SD] age at baseline, 55.4 [6.1] years), 3695 (8.0%) achieved healthy aging after 24 years of follow-up. After adjusting for established and potential confounders, compared with women who never worked rotating night shifts, the odds of achieving healthy aging decreased significantly with increasing duration of night shift work. The odds ratios were 0.96 (95% CI, 0.89-1.03) for 1 to 5 years, 0.92 (95% CI, 0.79-1.07) for 6 to 9 years, and 0.79 (95% CI, 0.69-0.91) for 10 or more years of night shift work (P = .001 for trend). This association did not differ substantially by age and lifestyles and was consistent for 4 individual dimensions of healthy aging. Results were similar in a secondary analysis, with an odds ratio of 0.73 (95% CI, 0.60-0.89; P < .001 for trend) comparing 10 or more years of night shift work vs no night shift work. In this cohort study, rotating night shift work was associated with decreased probability of healthy aging among US female nurses. These data support the notion that excess night shift work is a significant health concern that may also lead to deteriorated overall health among older individuals.
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影响因子：
5.5
作者：
Gu F;Han J;Laden F;Pan A;Caporaso NE;Stampfer MJ;Kawachi I;Rexrode KM;Willett WC;Hankinson SE;Speizer FE;Schernhammer ES
通讯作者：
Schernhammer ES
影响因子：
3.7
作者：
Bosch-Farré C;Garre-Olmo J;Bonmatí-Tomàs A;Malagón-Aguilera MC;Gelabert-Vilella S;Fuentes-Pumarola C;Juvinyà-Canal D
通讯作者：
Juvinyà-Canal D
影响因子：
6.3
作者：
Jorgensen, Jeanette Therming;Karlsen, Sashia;Andersen, Zorana Jovanovic
通讯作者：
Andersen, Zorana Jovanovic
影响因子：
5.7
作者：
Lopez, Oscar L;Kuller, Lewis H
通讯作者：
Kuller, Lewis H
DOI：
10.1097/01.jgp.0000192501.03069.bc
发表时间：
2006-01-01
影响因子：
7.2
作者：
Depp, CA;Jeste, DV
通讯作者：
Jeste, DV