Cortical signature of patients with HBV-related cirrhosis without overt hepatic encephalopathy: a morphometric analysis.
Cortical signature of patients with HBV-related cirrhosis without overt hepatic encephalopathy: a morphometric analysis.
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无明显肝性脑病的 HBV 相关肝硬化患者的皮质特征：形态测量分析。
DOI：
10.3389/fnana.2015.00082
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发表时间：
2015
影响因子：
2.9
通讯作者：
Jiang GH
中科院分区：
文献类型：
--
作者：
Wu X;Lv XF;Zhang YL;Wu HW;Cai PQ;Qiu YW;Zhang XL;Jiang GH
既往研究表明，无明显肝性脑病（OHE）的B型肝炎病毒相关肝硬化（HBV-RC）患者存在不同程度的认知功能障碍。一些静息态功能磁共振成像（fMRI）的研究已经进行了探索这种认知缺陷的神经相关性，而很少有人努力调查没有OHE的阿尔茨海默病患者的皮质完整性。在这里，使用皮质厚度，表面积和局部回旋指数（lGI），本研究进行了全面的分析与HBV-RC无OHE（HBV-RC-NOHE）患者与匹配的健康对照组的皮质形态。与健康对照组相比，HBV-RC-NOHE患者双侧舌回、海马旁回、右侧扣带回后部、楔前叶、距状核周围沟、梭状回皮质厚度明显增加，可能与轻度脑水肿密切相关。皮质回转分析显示左侧上级和下顶叶皮质以及外侧枕叶皮质中的lGI显著增加，推测其与白色物质连通性和次优皮质内组织的破坏相关。此外，HBV-RC-NOHE患者结构异常区域的平均皮质厚度/lGI与心理测量肝性脑病评分（PHES）呈负相关。这些形态学变化可能作为HBV-RC-NOHE临床前诊断和进展的潜在标志物。
Previous studies have shown that patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt hepatic encephalopathy (OHE) are associated with a varying degree of cognitive dysfunction. Several resting-state functional magnetic resonance imaging (fMRI) studies have been conducted to explore the neural correlates of such cognitive deficits, whereas little effort has been made to investigate the cortical integrity in cirrhotic patients without OHE. Here, using cortical thickness, surface area and local gyrification index (lGI), this study performed a comprehensive analysis on the cortical morphometry of patients with HBV-RC without OHE (HBV-RC-NOHE) vs. matched healthy controls. Compared with healthy controls, we found significantly increased cortical thickness in the bilateral lingual and parahippocampal gyrus, right posterior cingulate cortex, precuneus, peri-calcarine sulcus and fusiform gyrus in patient with HBV-RC-NOHE, which may closely relate to be the low-grade brain edema. Cortical gyrification analysis showed significantly increased lGI in the left superior and inferior parietal cortex as well as lateral occipital cortex, which was speculated to be associated with disruptions in white matter connectivity and sub-optimal intra-cortical organization. In addition, the mean cortical thickness/lGI of the regions with structural abnormalities was shown to be negatively correlated with psychometric hepatic encephalopathy score (PHES) of the patients with HBV-RC-NOHE. These morphological changes may serve as potential markers for the preclinical diagnosis and progression of HBV-RC-NOHE.
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